2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Abetimus

Abetimus (LJP 394 free base) is an immunosuppressant consisting of four double-stranded DNA (dsDNA) oligonucleotides. Abetimus is capable of crosslinking anti-dsDNA antibodies on the surface of B cells, and decreases anti-dsDNA antibodies levels. Abetimus has the potential for research of systemic lupus erythematosus.

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DNA, d(C-A-C-A-C-A-C-A-C-A-C-A-C-A-C-A-C-A-C-A), 5′-ester with 1,2-ethanediylbis(oxy-2,1-ethanediyl)bis[2-(21,21-dihydroxy-21-oxido-4,11-dioxo-20-oxa-13-thia-3,10-diaza-21-phosphaheneicos-1-yl)-23,23-dihydroxy-23-oxido-6,13-dioxo-22-oxa-15-thia-2,5,12-triaza-23-phosphatricosanoate] (4:1), complex with DNA d(T-G-T-G-T-G-T-G-T-G-T-G-T-G-T-G-T-G-T-G) (1:1)

Abetimus Estructura química

No. CAS : 167362-48-3

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Abetimus Related Antibodies

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Descripciòn

Abetimus (LJP 394 free base) is an immunosuppressant consisting of four double-stranded DNA (dsDNA) oligonucleotides. Abetimus is capable of crosslinking anti-dsDNA antibodies on the surface of B cells, and decreases anti-dsDNA antibodies levels. Abetimus has the potential for research of systemic lupus erythematosus[1].

In Vitro

Administration of Abetimus (LJP 394 free base) is thought to reduce circulating anti-dsDNA Abs by at least two mechanisms. First, Abetimus (LJP 394 free base) acutely depletes circulating anti-dsDNA antibodies, presumably by forming small, soluble complexes that do not appear to result in significant activation of the complement system. Second, Abetimus (LJP 394 free base) binds B cells without T-cell activation, resulting in their apoptosis and reduced anti-dsDNA antibody production. In fact, Abetimus (LJP 394 free base) appears to induce B-cell tolerance by crosslinking anti-dsDNA surface immunoglobulin receptors on B cells and triggering the signal transduction pathways that lead to B-cell anergy or apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abetimus Related Antibodies
In Vivo

Abetimus (LJP 394 free base) proves effective in suppressing anti-dsDNA-mediated pathologies in male BXSB mice, a model for systemic lupus. Mice dosed with Abetimus (3-300 μg/mouse) i.v. twice weekly, starting around nine weeks of age, has significantly lower titers of anti-dsDNA, lower numbers of anti-dsDNA-secreting spleen cells and less adverse renal histopathology than control mice[2].
Abetimus has a pharmacokinetic half-life ranging from 40 min to 1 h in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
Peso molecular

50742.05

Fòrmula

C1632H2100N610O97P156S4
No. CAS
SMILES

[Abetimus]
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Abetimus Related Classifications

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Keywords:

Abetimus167362-48-3LJP 394LJP394LJP-394DNA/RNA Synthesisimmunosuppressantdouble-stranded DNA oligonucleotidesanti-dsDNA antibodiessystemic lupus erythematosusB cellsInhibitorinhibitorinhibit

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