Ac-Lys-Val-Cit-PABC-MMAE formic

Name: Ac-Lys-Val-Cit-PABC-MMAE formic
Brand: MedChemExpress
SKU: HY-147286A
Rating: 4.5 (0 reviews)

Cat. No.: HY-147286A Purity: 99.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Ac-Lys-Val-Cit-PABC-MMAE (formic) is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitorMonomethyl auristatin E (HY-15162).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Ac-Lys-Val-Cit-PABC-MMAE formic 화학구조

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Ac-Lys-Val-Cit-PABC-MMAE formic:

Ac-Lys-Val-Cit-PABC-MMAE In-stock

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•Related Small Molecules:

•Related Proteins:

View All Drug-Linker Conjugates for ADC Isoform Specific Products:

View All Isoforms

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

1339.66

화학식

C₆₇H₁₁₀N₁₂O₁₆

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)OC)=O.OC=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMSO : 200 mg/mL (149.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7465 mL	3.7323 mL	7.4646 mL
5 mM	0.1493 mL	0.7465 mL	1.4929 mL
10 mM	0.0746 mL	0.3732 mL	0.7465 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.96%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (250 KB) HNMR (517 KB) RP-HPLC (265 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Kleniman, et al. Engineered polypeptide conjugates. WO2015015448A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7465 mL	3.7323 mL	7.4646 mL	18.6615 mL
	5 mM	0.1493 mL	0.7465 mL	1.4929 mL	3.7323 mL
	10 mM	0.0746 mL	0.3732 mL	0.7465 mL	1.8661 mL
	15 mM	0.0498 mL	0.2488 mL	0.4976 mL	1.2441 mL
	20 mM	0.0373 mL	0.1866 mL	0.3732 mL	0.9331 mL
	25 mM	0.0299 mL	0.1493 mL	0.2986 mL	0.7465 mL
	30 mM	0.0249 mL	0.1244 mL	0.2488 mL	0.6220 mL
	40 mM	0.0187 mL	0.0933 mL	0.1866 mL	0.4665 mL
	50 mM	0.0149 mL	0.0746 mL	0.1493 mL	0.3732 mL
	60 mM	0.0124 mL	0.0622 mL	0.1244 mL	0.3110 mL
	80 mM	0.0093 mL	0.0467 mL	0.0933 mL	0.2333 mL
	100 mM	0.0075 mL	0.0373 mL	0.0746 mL	0.1866 mL