Ac-Lys-Val-Cit-PABC-MMAE

Cat. No.: HY-147286 Purity: 99.99%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Ac-Lys-Val-Cit-PABC-MMAE is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor MMAE (HY-15162).

For research use only. We do not sell to patients.

Ac-Lys-Val-Cit-PABC-MMAE Chemical Structure

CAS No. : 1650569-89-3

Size	Price	Stock	Quantity
5 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 720	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Ac-Lys-Val-Cit-PABC-MMAE:

Ac-Lys-Val-Cit-PABC-MMAE formic In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Auristatin

Molecular Weight

1293.64

Formula

C₆₆H₁₀₈N₁₂O₁₄

CAS No.

1650569-89-3

Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 200 mg/mL (154.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7730 mL	3.8651 mL	7.7301 mL
5 mM	0.1546 mL	0.7730 mL	1.5460 mL
10 mM	0.0773 mL	0.3865 mL	0.7730 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.99%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (249 KB) HNMR (545 KB) RP-HPLC (262 KB)

Handling Instructions (2659 KB)

References

[1]. Kleniman, et al. Engineered polypeptide conjugates. WO2015015448A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7730 mL	3.8651 mL	7.7301 mL	19.3253 mL
	5 mM	0.1546 mL	0.7730 mL	1.5460 mL	3.8651 mL
	10 mM	0.0773 mL	0.3865 mL	0.7730 mL	1.9325 mL
	15 mM	0.0515 mL	0.2577 mL	0.5153 mL	1.2884 mL
	20 mM	0.0387 mL	0.1933 mL	0.3865 mL	0.9663 mL
	25 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.7730 mL
	30 mM	0.0258 mL	0.1288 mL	0.2577 mL	0.6442 mL
	40 mM	0.0193 mL	0.0966 mL	0.1933 mL	0.4831 mL
	50 mM	0.0155 mL	0.0773 mL	0.1546 mL	0.3865 mL
	60 mM	0.0129 mL	0.0644 mL	0.1288 mL	0.3221 mL
	80 mM	0.0097 mL	0.0483 mL	0.0966 mL	0.2416 mL
	100 mM	0.0077 mL	0.0387 mL	0.0773 mL	0.1933 mL