2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Ac-Lys-Val-Cit-PABC-MMAE formic

Ac-Lys-Val-Cit-PABC-MMAE formic 

Cat. No.: HY-147286A Purity: 99.96%
COA Handling Instructions

Molarity Calculator

Ac-Lys-Val-Cit-PABC-MMAE (formic) is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor auristatin E.html" class="link-product" target="_blank"> Monomethyl auristatin E (HY-15162).

For research use only. We do not sell to patients.

Ac-Lys-Val-Cit-PABC-MMAE formic Chemical Structure

Ac-Lys-Val-Cit-PABC-MMAE formic Chemical Structure

Size Price Stock Quantity
5 mg USD 450 In-stock
10 mg USD 720 In-stock
25 mg USD 1500 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Ac-Lys-Val-Cit-PABC-MMAE formic:

Ac-Lys-Val-Cit-PABC-MMAE formic Related Antibodies

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Description

Ac-Lys-Val-Cit-PABC-MMAE (formic) is a agent-linker conjugate for ADC. Ac-Lys-Val-Cit-PABC-MMAE contains the ADC linker (peptide Ac-Lys-Val-Cit-PABC) and a potent tubulin polymerization inhibitor auristatin E.html" class="link-product" target="_blank"> Monomethyl auristatin E (HY-15162)[1].

Molecular Weight

1339.66

Formula

C67H110N12O16
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)OC)=O.OC=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (149.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7465 mL 3.7323 mL 7.4646 mL
5 mM 0.1493 mL 0.7465 mL 1.4929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7465 mL 3.7323 mL 7.4646 mL 18.6615 mL
5 mM 0.1493 mL 0.7465 mL 1.4929 mL 3.7323 mL
10 mM 0.0746 mL 0.3732 mL 0.7465 mL 1.8661 mL
15 mM 0.0498 mL 0.2488 mL 0.4976 mL 1.2441 mL
20 mM 0.0373 mL 0.1866 mL 0.3732 mL 0.9331 mL
25 mM 0.0299 mL 0.1493 mL 0.2986 mL 0.7465 mL
30 mM 0.0249 mL 0.1244 mL 0.2488 mL 0.6220 mL
40 mM 0.0187 mL 0.0933 mL 0.1866 mL 0.4665 mL
50 mM 0.0149 mL 0.0746 mL 0.1493 mL 0.3732 mL
60 mM 0.0124 mL 0.0622 mL 0.1244 mL 0.3110 mL
80 mM 0.0093 mL 0.0467 mL 0.0933 mL 0.2333 mL
100 mM 0.0075 mL 0.0373 mL 0.0746 mL 0.1866 mL
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Ac-Lys-Val-Cit-PABC-MMAE formic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Lys-Val-Cit-PABC-MMAEDrug-Linker Conjugates for ADCcancerconjugateADClinkertubulinInhibitorinhibitorinhibit

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