Adenosine phosphonobutyric, 2'(3'), 5'-diposphate
Adenosine phosphonobutyric, 2'(3'), 5'-diposphate (APBADP) is an adenylosuccinate lyase substrate analog and competitive inhibitor. Adenosine phosphonobutyric, 2'(3'), 5'-diposphate binds to the tetramers of *Bacillus subtilis* adenylosuccinate lyase and wild-type human adenylosuccinate lyase. Adenosine phosphonobutyric, 2'(3'), 5'-diposphate can be used for research on adenylosuccinate lyase deficiency.
For research use only. We do not sell to patients.
- CAS No.: 1050202-63-5
- Formula: C14H22N5O16P3
- Molecular Weight:609.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
adenylosuccinate lyase (ASL)[1]
In Vitro
Adenosine phosphonobutyric, 2'(3'), 5'-diphosphate (0-1 μM; 30 min) acts as a competitive inhibitor of wild-type Bacillus subtilis adenylosuccinate lyase, targeting the substrates SAMP and SAICAR with Ki values of 0.18 μM and 0.16 μM, respectively[1].
APBADP (0.25-1.0 μM; 30 min) acts as a competitive inhibitor of wild-type human adenylosuccinate lyase against the substrates SAMP and SAICAR, with Ki values of 0.09 μM and 0.21 μM, respectively[1].
APBADP (30 μM) binds to mutant adenylosuccinate lyase variants of *Bacillus subtilis* (H141Q, H68A, H89Q, H89R, D69N), with a binding level comparable to that of the wild-type enzyme[1].
APBADP (30 μM) binds to serine-mutated variants of *Bacillus subtilis* and *Homo sapiens* adenylosuccinate lyase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1050202-63-5
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Molecular Weight 609.27
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Formula C14H22N5O16P3
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SMILES
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O[C@H]1N2C(N=CN=C3NC(C(O)=O)CCOP(O)(O)=O)=C3N=C2
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Synonyms
APBADP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adenosine phosphonobutyric, 2'(3'), 5'-diposphate Related Classifications
HY-158987 Related Classifications
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