2. Stem Cell/Wnt TGF-beta/Smad
  3. RUNX
  4. AI-10-47

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM.

Para uso exclusivo en investigación. No vendemos a pacientes.

AI-10-47

AI-10-47 Estructura química

No. CAS : 1256094-31-1

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 publication(s) in Google Scholar

AI-10-47 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas RUNX:

Ver todas las isoformas
RUNX1 RUNX2

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1].

In Vitro

AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].
AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AI-10-47 Related Antibodies

Western Blot Analysis[1]

Cell Line: 4 × 106 SEM cells.
Concentration: 10 μM.
Incubation Time: 6 h.
Result: Weakly reduced CBFβ binding to RUNX1 in cells (may due to its poor solubility).
Peso molecular

279.22

Fòrmula

C13H8F3N3O
No. CAS
Appearance

Solid

Color

Off-white to gray

SMILES

FC(F)(F)OC1=CC=C2N=C(C3=NC=CC=C3)NC2=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (358.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5814 mL 17.9070 mL 35.8141 mL
5 mM 0.7163 mL 3.5814 mL 7.1628 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5814 mL 17.9070 mL 35.8141 mL 89.5351 mL
5 mM 0.7163 mL 3.5814 mL 7.1628 mL 17.9070 mL
10 mM 0.3581 mL 1.7907 mL 3.5814 mL 8.9535 mL
15 mM 0.2388 mL 1.1938 mL 2.3876 mL 5.9690 mL
20 mM 0.1791 mL 0.8954 mL 1.7907 mL 4.4768 mL
25 mM 0.1433 mL 0.7163 mL 1.4326 mL 3.5814 mL
30 mM 0.1194 mL 0.5969 mL 1.1938 mL 2.9845 mL
40 mM 0.0895 mL 0.4477 mL 0.8954 mL 2.2384 mL
50 mM 0.0716 mL 0.3581 mL 0.7163 mL 1.7907 mL
60 mM 0.0597 mL 0.2985 mL 0.5969 mL 1.4923 mL
80 mM 0.0448 mL 0.2238 mL 0.4477 mL 1.1192 mL
100 mM 0.0358 mL 0.1791 mL 0.3581 mL 0.8954 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AI-10-47 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AI-10-471256094-31-1RUNXRunt-related transcription factorsCBFβME-1TURM0-91THP-1U937leukemiacellInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
AI-10-47
Cat. No.:
HY-138617
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.