all-trans-Anhydro Retinol (Synonyms: Anhydrovitamin A)

製品番号: HY-N7495 純度: 94.94%: Data Sheet SDS COA 取扱説明書
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all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body.

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all-trans-Anhydro Retinol 構造式

CAS 番号 : 1224-78-8

容量	価格（税別）	在庫状況	数量
5 mg	$130	在庫あり	Estimated Time of Arrival: December 31
10 mg	$220	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of all-trans-Anhydro Retinol:

all-trans-Anhydro Retinol (Standard) お問い合わせ

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体内実験

all-trans-Anhydro Retinol (2.22 mg; oral administration/subcutaneous injection; 6 days) in Vitamin A (HY-B1342)-deficient rats shows that it is metabolized into various monohydroxy, dihydroxy and ester derivatives through hydroxylation and esterification, with no detectable Vitamin A (HY-B1342) or unmetabolized Anhydrovitamin A in the liver^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (approximately 7 weeks old) made Vitamin A (HY-B1342)-deficient by dietary restriction^[1]
Dosage:	0.22 mg/0.1 mL
Administration:	Oral administration/subcutaneous injection; 6 days
Result:	Was metabolized into at least seven derivatives in the liver, including non-hydroxy, monohydroxy, and dihydroxy compounds with ester groups. The metabolites were poorly absorbed and stored, with no detectable levels remaining in the liver after 30 days. Resulted in 26% of the liver storage by subcutaneous injection compared to oral administration. The growth-promoting activity was attributed to the in vivo-formed derivatives rather than conversion to vitamin A.

分子量

268.44

分子式

C₂₀H₂₈

CAS 番号

1224-78-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1(C)CCC=C(C)/C1=C/C=C(C)/C=C/C=C(C)/C=C

Structure Classification

Initial Source

Endogenous metabolite

輸送条件

Shipping with dry ice.

保管条件

-80°C, protect from light, stored under nitrogen

溶剤 & 溶解度

体外:

DMSO : 10 mg/mL (37.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7252 mL	18.6261 mL	37.2523 mL
5 mM	0.7450 mL	3.7252 mL	7.4505 mL
10 mM	0.3725 mL	1.8626 mL	3.7252 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 97.01%

Select Batch:

データシート (269 KB) SDS (252 KB)

COA (243 KB) HNMR (234 KB) LCMS (104 KB) Elemental Analysis Report (100 KB)

取扱説明書 (2659 KB)

参考文献

[1]. T N Varma, et al. The Utilization of Anhydrovitamin A by the Vitamin A-deficient Rat. Biochim Biophys Acta. 1965 Jun 15;104(1):71-7. [Content Brief]

[2]. T HIGUCHI, et al. Kinetics of Formation of Anhydrovitamin A From Vitamin A Alcohol and Its Acetate. J Am Pharm Assoc Am Pharm Assoc. 1959 Mar;48(3):155-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7252 mL	18.6261 mL	37.2523 mL	93.1307 mL
	5 mM	0.7450 mL	3.7252 mL	7.4505 mL	18.6261 mL
	10 mM	0.3725 mL	1.8626 mL	3.7252 mL	9.3131 mL
	15 mM	0.2483 mL	1.2417 mL	2.4835 mL	6.2087 mL
	20 mM	0.1863 mL	0.9313 mL	1.8626 mL	4.6565 mL
	25 mM	0.1490 mL	0.7450 mL	1.4901 mL	3.7252 mL
	30 mM	0.1242 mL	0.6209 mL	1.2417 mL	3.1044 mL

all-trans-Anhydro Retinol Related Classifications

Metabolic Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

all-trans-Anhydro Retinol1224-78-8Anhydrovitamin ADrug MetaboliteVitamin AMetaboliteInhibitorinhibitorinhibit

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