2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GlyT
  4. ALX-1393

ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model.

Both the free form and hydrochloride salt form of the compound are susceptible to instability. It is recommended to opt for the stable trifluoroacetic acid (TFA) salt form (ALX-1393 TFA), which maintains equivalent biological activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

ALX-1393

ALX-1393 Estructura química

No. CAS : 949164-09-4

Tamaño Stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  
250 mg   Obtener un presupuesto  

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of ALX-1393:

Other Forms of ALX-1393:

ALX-1393 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas GlyT:

Ver todas las isoformas
GlyT1 GlyT2

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

ALX-1393, a selective GlyT2 inhibitor, has an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model[1].

IC50 & Target[1]

GlyT2

 

Cellular Effect
Cell Line Type Value Description References
COS-7 IC50
21.1 nM
Compound: ALX1393
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
Inhibition of [3H]glycine uptake at rat glycine transporter 2 expressed in african green monkey COS7 cells
[PMID: 19013063]
In Vivo

ALX1393 (i.c.v.; 25, 50, and 100 μg) in normal rats suppresses the late-phase response in the formalin test but does not affect motor performance. ALX1393 inhibits mechanical and cold hyperalgesia in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

395.42

Fòrmula

C23H22FNO4
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](COC(C1=CC=CC(F)=C1)C2=CC=CC=C2OCC3=CC=CC=C3)C(O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Pureza y Documentación
Referencias
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ALX-1393 Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALX-1393949164-09-4ALX1393ALX 1393GlyTGlycine transportersInhibitorinhibitorinhibit

Productos vistos recientemente:

Consulta en línea

Your information is safe with us. * Required Fields.

Nombre del producto

  

Requested Quantity *

Nombre del solicitante *

 

Saludo

Direcciòn del E-mail *

 

Número de teléfono *

Department

 

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

      

Observaciones

Consulta para venta a granel

Inquiry Information

Nombre del producto:
ALX-1393
Cat. No.:
HY-111029
Cantidad:
MCE Japan Authorized Agent:

Revisión del cliente

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Nombre del producto

  

Lot #

Nombre del solicitante *

 

Direcciòn del E-mail *

Número de teléfono

 

Department *

Nombre de la Organizaciòn *

 

Country or Region *

Observaciones

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.