Angiotensin I/II (1-6) (TFA)

Name: Angiotensin I/II (1-6) (TFA)
Brand: MedChemExpress
SKU: HY-P1829A
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1829A Purity: 98.69%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Angiotensin I/II (1-6) TFA contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I ishydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin I/II (1-6) (TFA) Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Angiotensin I/II (1-6) (TFA):

Angiotensin I/II (1-6) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Angiotensin II is a naturally occurring octapeptide hormone component of the renin-angiotensin-aldosterone system (RAAS) and is a potent vasoconstrictor. Angiotensin II has important roles in cardiovascular, neurologic, and renal physiology, including maintenance of blood pressure, thirst sensation, response to the baroreceptor reflex, determination of renal blood flow and glomerular filtration rate, and electrolyte and free water homeostasis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

915.91

Formula

C₃₈H₅₆F₃N₁₁O₁₂

Appearance

Solid

Color

White to off-white

Sequence

Asp-Arg-Val-Tyr-Ile-His

Sequence Shortening

DRVYIH

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (109.18 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (109.18 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0918 mL	5.4591 mL	10.9181 mL
5 mM	0.2184 mL	1.0918 mL	2.1836 mL
10 mM	0.1092 mL	0.5459 mL	1.0918 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.69%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (252 KB) RP-HPLC (112 KB) MS (213 KB) Elemental Analysis Report (111 KB)

Handling Instructions (2659 KB)

References

[1]. Erdös EG, et al. Conversion of angiotensin I to angiotensin II. Am J Med. 1976 May 31;60(6):749-59. [Content Brief]

[2]. Busse LW, et al. Clinical Experience With IV Angiotensin II Administration: A Systematic Review of Safety. Crit Care Med. 2017;45(8):1285-1294. [Content Brief]

[3]. Angiotensin II.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.0918 mL	5.4591 mL	10.9181 mL	27.2953 mL
	5 mM	0.2184 mL	1.0918 mL	2.1836 mL	5.4591 mL
	10 mM	0.1092 mL	0.5459 mL	1.0918 mL	2.7295 mL
	15 mM	0.0728 mL	0.3639 mL	0.7279 mL	1.8197 mL
	20 mM	0.0546 mL	0.2730 mL	0.5459 mL	1.3648 mL
	25 mM	0.0437 mL	0.2184 mL	0.4367 mL	1.0918 mL
	30 mM	0.0364 mL	0.1820 mL	0.3639 mL	0.9098 mL
	40 mM	0.0273 mL	0.1365 mL	0.2730 mL	0.6824 mL
	50 mM	0.0218 mL	0.1092 mL	0.2184 mL	0.5459 mL
	60 mM	0.0182 mL	0.0910 mL	0.1820 mL	0.4549 mL
	80 mM	0.0136 mL	0.0682 mL	0.1365 mL	0.3412 mL
	100 mM	0.0109 mL	0.0546 mL	0.1092 mL	0.2730 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.