2. Apoptosis Immunology/Inflammation
  3. Pyroptosis NOD-like Receptor (NLR)
  4. Antcin A

Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Antcin A

Antcin A 構造式

CAS 番号 : 163597-24-8

容量 価格（税別） 在庫状況 数量
1 mg $280 在庫あり
5 mg $875 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Antcin A 関連抗体

Top Publications Citing Use of Products

NOD-like Receptor (NLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NLRP3 NLRP1 NOD1 NOD2

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Antcin A is a potent NLRP3 inhibitor that inhibits the assembly and activation of the NLRP3 inflammasome. Antcin A can inhibit Kupffer cell pyroptosis and has liver protective activity. Antcin A can be used to study inflammation, such as non-alcoholic fatty liver disease[1].

IC50 & Target

NLRP3[1].
Cellular Effect
Cell Line Type Value Description References
A549 IC50
39.4 3
Compound: 17
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24387703]
A549 IC50
39.4 3
Compound: 17
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24387703]
A549 IC50
39.4 3
Compound: 17
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
[PMID: 24387703]
BV-2 IC50
4.1 3
Compound: 15
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
[PMID: 21028898]
BV-2 IC50
4.1 3
Compound: 15
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
[PMID: 21028898]
BV-2 IC50
4.1 3
Compound: 15
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced iNOS-dependent nitrite production after 24 hrs by Griess method
[PMID: 21028898]
Daoy ED50
13.2 6
Compound: 30
Cytotoxicity against human DaOY cells after 3 days by MTT assay
Cytotoxicity against human DaOY cells after 3 days by MTT assay
[PMID: 21115251]
BV-2 IC50
45.9 3
Compound: 15
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of NOX-dependent ROS production up to 50 uM
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of NOX-dependent ROS production up to 50 uM
[PMID: 21028898]
BV-2 IC50
45.9 3
Compound: 15
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of NOX-dependent ROS production up to 50 uM
Antiinflammatory activity in mouse BV2 cells assessed as inhibition of NOX-dependent ROS production up to 50 uM
[PMID: 21028898]
Daoy ED50
13.2 6
Compound: 30
Cytotoxicity against human DaOY cells after 3 days by MTT assay
Cytotoxicity against human DaOY cells after 3 days by MTT assay
[PMID: 21115251]
HeLa ED50
> 20 6
Compound: 30
Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
[PMID: 21115251]
Daoy ED50
13.2 6
Compound: 30
Cytotoxicity against human DaOY cells after 3 days by MTT assay
Cytotoxicity against human DaOY cells after 3 days by MTT assay
[PMID: 21115251]
HeLa ED50
>20 6
Compound: 30
Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
[PMID: 21115251]
HEp-2 ED50
> 20 6
Compound: 30
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
[PMID: 21115251]
HEp-2 ED50
> 20 6
Compound: 30
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
[PMID: 21115251]
KB EC50
4.9 3
Compound: 15
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
[PMID: 21028898]
HEp-2 ED50
>20 6
Compound: 30
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
Cytotoxicity against human Hep2 cells after 3 days by MTT assay
[PMID: 21115251]
HeLa ED50
> 20 6
Compound: 30
Cytotoxicity against human HeLa cells after 3 days by MTT assay
Cytotoxicity against human HeLa cells after 3 days by MTT assay
[PMID: 21115251]
KB EC50
4.9 3
Compound: 15
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
[PMID: 21028898]
KB EC50
4.9 3
Compound: 15
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay
[PMID: 21028898]
MCF7 ED50
13.3 6
Compound: 30
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
[PMID: 21115251]
MDA-MB-231 IC50
29.6 3
Compound: 17
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 24387703]
MCF7 ED50
13.3 6
Compound: 30
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
[PMID: 21115251]
MCF7 ED50
13.3 6
Compound: 30
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
[PMID: 21115251]
MDA-MB-231 IC50
29.6 3
Compound: 17
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 24387703]
MDA-MB-231 IC50
29.6 3
Compound: 17
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells after 48 hrs by SRB assay
[PMID: 24387703]
分子量

454.64

分子式

C29H42O4
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

C[C@@]12C3=C(CC[C@@]1([H])[C@@H](C(CC2)=O)C)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
Structure Classification
Initial Source

Antrodia cinnamomea
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
純度とドキュメンテーション
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Antcin A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antcin A163597-24-8PyroptosisNOD-like Receptor (NLR)inflammasomeinflammationNAFLDKupfferpyroptosisInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Antcin A
製品番号:
HY-N9921
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.