163597-24-8
Chemical Structure
Antcin A
- CAS No.: 163597-24-8
- Formula:C29H42O4
- Molecular Weight:454.64
IUPAC Name: (6R)-2-methyl-3-methylene-6-((4S,5S,10S,13R,14R,17R)-4,10,13-trimethyl-3,11-dioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)heptanoic acid
InChIKey: WTSUWKBKPMVEBO-QMHPZZQYSA-N
SMILES: C[C@@]12C3=C(CC[C@@]1([H])[C@@H](C(CC2)=O)C)[C@@]4([H])[C@](CC3=O)([C@@](CC4)([H])[C@H](C)CCC(C(C)C(O)=O)=C)C
Biological Activity: Antcin A is an orally active modulator of p53 and glucocorticoid receptor (GR), with an IC50 of 8.55 μM against human GR. Through transcriptional activation of p53, Antcin A induces miR-200c and inhibits ZEB1, regulates epithelial-mesenchymal transition markers, and suppresses cancer cell migration/invasion. Antcin A activates GR, inhibits Na+/K+-ATPase and NLRP3 inflammasome assembly, pyroptosis (pyroptosis) and pro-inflammatory cytokine release, reduces hepatic lipid deposition, improves liver function, and reverses metabolic changes induced by the SARS-CoV-2 spike protein. Antcin A can be used in research related to breast cancer, head and neck cancer, non-alcoholic fatty liver disease, and coronavirus disease 2019 (COVID-19)[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Antcin A | 99.71% | Antcin A is an orally active modulator of p53 and glucocorticoid receptor (GR), with an IC50 of 8.55 μM against human GR. Through transcriptional activation of p53, Antcin A induces miR-200c and inhibits ZEB1, regulates epithelial-mesenchymal transition markers, and suppresses cancer cell migration/invasion. Antcin A activates GR, inhibits Na+/K+-ATPase and NLRP3 inflammasome assembly, pyroptosis (pyroptosis) and pro-inflammatory cytokine release, reduces hepatic lipid deposition, improves liver function, and reverses metabolic changes induced by the SARS-CoV-2 spike protein. Antcin A can be used in research related to breast cancer, head and neck cancer, non-alcoholic fatty liver disease, and coronavirus disease 2019 (COVID-19). | ||||||||||||||||||||
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References
- [1]. Senthil Kumar K J, et al. Antcin‑A Modulates Epithelial‑to‑Mesenchymal Transition and Inhibits Migratory and Invasive Potentials of Human Breast Cancer Cells via p53‑Mediated miR‑200c Activation. Planta Med. 2019, 85, 09/10.
- [2]. Senthil Kumar KJ, et al. A mechanistic and empirical review of antcins, a new class of phytosterols of formosan fungi origin. Journal of food and drug analysis. 2020 Jan;28(1):38-59.
- [3]. Chen YC, et al. Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids. Acta pharmacologica Sinica. 2011 Jul;32(7):904-11.
- [4]. Ruan S, et al. Antcin A alleviates pyroptosis and inflammatory response in Kupffercells of non-alcoholic fatty liver disease by targeting NLRP3. Int Immunopharmacol. 2021 Nov;100:108126. [Content Brief]
- [5]. Dakpa G, et al. Antcin A, a phytosterol regulates SARS-CoV-2 spike protein-mediated metabolic alteration in THP-1 cells explored by the H-NMR-based metabolomics approach. Phytotherapy research : PTR. 2023 Mar;37(3):885-902.
- [6]. I-Hwa Cherng, et al. Three New Triterpenoids from Antrodia cinnamomea. J. Nat. Prod. 1 March 1995; 58 (3): 365–371.
