2. Others Membrane Transporter/Ion Channel
  3. MOFs Chloride Channel
  4. Anthracene-9-carboxylic acid

Anthracene-9-carboxylic acid  (Synonyms: 9-Anthracenecarboxylic acid; 9-アントラセンカルボン酸; 9-アントロン酸)

製品番号: HY-101329 純度: 99.21%
COA 取扱説明書 Technical Support

Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells.

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Anthracene-9-carboxylic acid

Anthracene-9-carboxylic acid 構造式

CAS 番号 : 723-62-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in DMSO USD 33 在庫あり
Solid
500 mg $30 在庫あり
1 g $50 在庫あり
5 g   お問い合わせ  
10 g   お問い合わせ  

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Other Forms of Anthracene-9-carboxylic acid:

Anthracene-9-carboxylic acid 関連抗体

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製品説明

Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[1].

IC50 & Target

Ca2+-activated Cl- currents[1]
体外実験

Anthracene-9-carboxylic acid causes a voltage-dependent block of outward currents in HEK 293T cells and inhibits a larger fraction of the current as depolarization increased[1].
Anthracene-9-carboxylic acid induces a strong potentiation of tail currents measured at -100 mV after depolarizing voltages, as well as a prolongation of the deactivation kinetics in HEK 293T[1].
Anthracene-9-carboxylic acid (500 μM, rabbit pulmonary artery smooth muscle cells) produces a small inhibition of the maximum outward Cl- current at +70 mV (21±10%) but augmented the amplitude of the instantaneous inward relaxation at -80 mV by 321±34%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anthracene-9-carboxylic acid 関連抗体
分子量

222.24

分子式

C15H10O2
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C2C=CC=CC2=CC3=CC=CC=C13)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (449.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4996 mL 22.4982 mL 44.9964 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL
10 mM 0.4500 mL 2.2498 mL 4.4996 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (22.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (22.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.21%

COA (255 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4996 mL 22.4982 mL 44.9964 mL 112.4910 mL
5 mM 0.8999 mL 4.4996 mL 8.9993 mL 22.4982 mL
10 mM 0.4500 mL 2.2498 mL 4.4996 mL 11.2491 mL
15 mM 0.3000 mL 1.4999 mL 2.9998 mL 7.4994 mL
20 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
25 mM 0.1800 mL 0.8999 mL 1.7999 mL 4.4996 mL
30 mM 0.1500 mL 0.7499 mL 1.4999 mL 3.7497 mL
40 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
50 mM 0.0900 mL 0.4500 mL 0.8999 mL 2.2498 mL
60 mM 0.0750 mL 0.3750 mL 0.7499 mL 1.8748 mL
80 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
100 mM 0.0450 mL 0.2250 mL 0.4500 mL 1.1249 mL
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Anthracene-9-carboxylic acid Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anthracene-9-carboxylic acid723-62-69-Anthracenecarboxylic acidMOFsChloride ChannelMetal-Organic FrameworksCl− ChannelsChloride currentanthracenesmooth muscle cellsInhibitorinhibitorinhibit

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製品名:
Anthracene-9-carboxylic acid
製品番号:
HY-101329
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