Anti-Mouse CD205 Antibody (NLDC-145) 

Anti-Mouse CD205 Antibody (NLDC-145) is a rat-derived IgG2aκ type antibody inhibitor, targeting to mouse CD205. Anti-Mouse CD205 Antibody (NLDC-145) reacts with CD205 also known as DEC-205. Anti-Mouse CD205 Antibody (NLDC-145) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as colitis, D2F2/E2 tumor and diabetes^[1][2][3].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

CD205

Anti-Mouse CD205 Antibody (NLDC-145) (Ins2 cDNA in frame with the C terminus of the H chain of an NLDC-145) binds to insulin polyclonal Ab^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD205 Antibody (NLDC-145) (1 μg, i.p., at days -2 and -1) reduces inflammation in conjugation of the HA_110-120 peptide in in colitis VILLIN-HA transgenic mice transferred with CD4⁺Foxp3⁻ T cells^[1].
Anti-Mouse CD205 Antibody (NLDC-145) (complex composed of the extracellular domain of HER2/neu and the NLDC-145 antibody) (50 μg, intramuscular injection, at days-21 and -7) inhibits tumor growth and increases survival rate in D2F2/E2 tumor mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

17076  [NCBI]

Q60767

in vivo antigen-targeting to DEC-205; in vitro antigen-targeting to DEC-205; Immunohistochemistry

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CD205 Antibody (NLDC-145)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wadwa M, et al. Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice. Eur J Microbiol Immunol (Bp). 2016 Jan 27;6(1):1-8.  [Content Brief]

  [2]. Cao J, et al. DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice. BMC Immunol. 2013 Aug 14;14:39.  [Content Brief]

  [3]. Schloss J, et al. Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes. Immunohorizons. 2019 Jun 26;3(6):236-253.  [Content Brief]