Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) 

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) is a mouse-derived IgG2a κ type antibody inhibitor targeting to mouse CTLA-4/CD152. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) contains a LALA-PG mutation in the Fc fragment rendering it unable to bind to endogenous Fcγ receptors. Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) can be used for the researches of cancer and immunology, such as colon^[1][2].

Mouse IgG2a (LALA-PG)

Mouse IgG2a (LALA-PG), Isotype Control

Mouse

CTLA-4/CD152

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) (500 μg at 1 day before injection, 250 μg at day 2 and 5, i.p.) increases regulatory T cells, T follicular helper and T follicular regulatory cells in NP-2W1S-GFP transferred mice^[1].
Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) (15 mg/kg, i.p., a single dose) shows potent anti-tumor effect in colon 26 tumor mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

12477  [NCBI]

P09793

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wing JB, et al. Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4. Immunity. 2014 Dec 18;41(6):1013-25.  [Content Brief]

  [2]. Bulliard Y, et al. Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies. J Exp Med. 2013 Aug 26;210(9):1685-93.  [Content Brief]