1. Gene
  2. Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

Mus musculus

Also known as Cd152; Ly-56; Ctla-4

Gene ID: 12477 | Gene type: protein coding

About Ctla4

Chromosome 1: 60,926,159-60,954,991 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 157 orthologues, 1 paralogue and is associated with 34 phenotypes. Biased expression in thymus adult (RPKM 1.4), spleen adult (RPKM .8) and 6 other tissues.

Summary

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Ctla4 Products(2)

mRNA Protein Name
NM_001281976.1 NP_001268905.1 cytotoxic T-lymphocyte protein 4 isoform 2 precursor
NM_009843.4 NP_033973.2 cytotoxic T-lymphocyte protein 4 isoform 1 precursor

Ctla4 Protein Structure

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 152)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 59)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 41)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (44 - 47)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (51 - 59)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (60 - 67)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (68 - 75)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (68 - 74)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (75 - 96)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (79 - 88)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (93 - 96)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (102 - 131)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (102 - 107)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (110 - 116)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (124 - 131)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (132 - 138)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (139 - 152)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (139 - 151)

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  • 223 a.a.
Protein Preferred Names Protein Names

cytotoxic T-lymphocyte protein 4

CD152 antigen

cytotoxic T-lymphocyte-associated antigen 4

Recombinant Ctla4 Proteins

Cat. No. Product Name Accession Purity
HY-P70706 CTLA-4 Protein, Mouse (125a.a, HEK293, Fc) P09793 (A37-D161) ≥95%
HY-P70804 CTLA-4, Mouse (HEK 293, His) P09793 (A37-D161) ≥95%
HY-P71991 CTLA-4 Protein, Mouse (125a.a, HEK293, His) P09793 (A37-D161) ≥95%
HY-P75317 CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) P09793 (E36-F162) ≥95%
HY-P75318 CTLA-4 Protein, Mouse (162a.a, HEK293, His) P09793 (M1-F162) ≥95%
HY-P75319 CTLA-4 Protein, Mouse (162a.a, HEK293, hFc) P09793 (M1-F162) ≥95%
HY-P78889 CTLA-4 Protein, Mouse (Biotinylated, HEK293, His-Avi) P09793  (E36-F162) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctla4 NCBI NCBI:1493
Canis familiaris Ctla4 NCBI NCBI:403696
Macaca fascicularis Ctla4 NCBI NCBI:102115124
Rattus norvegicus Ctla4 NCBI NCBI:63835
Macaca mulatta Ctla4 NCBI NCBI:705673