Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

Also Known as Cd152; Ly-56; Ctla-4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12477

About Ctla4

Chromosome 1: 60,926,159-60,954,991 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 157 orthologues, 1 paralogue and is associated with 34 phenotypes. Biased expression in thymus adult (RPKM 1.4), spleen adult (RPKM .8) and 6 other tissues.

Summary

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Ctla4 Products (2)

mRNA Protein Name
NM_001281976.1 NP_001268905.1 cytotoxic T-lymphocyte protein 4 isoform 2 precursor
NM_009843.4 NP_033973.2 cytotoxic T-lymphocyte protein 4 isoform 1 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence Références Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16227984 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctla4 Protein Structure

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 152)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 59)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (38 - 41)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (44 - 47)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (51 - 59)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (60 - 67)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (68 - 75)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (68 - 74)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (75 - 96)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (79 - 88)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (93 - 96)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (102 - 131)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (102 - 107)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (110 - 116)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (124 - 131)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (132 - 138)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (139 - 152)

IgV_CTLA-4

IgV_CTLA-4: cd05721 (139 - 151)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

cytotoxic T-lymphocyte protein 4

  • CD152 antigen

  • cytotoxic T-lymphocyte-associated antigen 4

Recombinant Ctla4 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70706 CTLA-4 Protein, Mouse (HEK293, Fc) P09793 (A37-D161) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71991 CTLA-4 Protein, Mouse (HEK293, His) P09793 (A37-D161) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75317 CTLA-4 Protein, Mouse (Biotinylated, HEK293, His) P09793 (E36-F162) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78889 CTLA-4 Protein, Mouse (Biotinylated, HEK293, His-Avi) P09793 (E36-F162) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (3)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-108829 Abatacept ≥99.0% Unkown
HY-P9901 Ipilimumab Inhibitor 99.88% Unkown
HY-P9918 Tremelimumab 99.50% Unkown

Clinical Phase

Inhibitory Antibodies (24)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P99540 Tuvonralimab Inhibitor 99.14% Phase 4
HY-P99117 Cadonilimab Inhibitor 99.87% Phase 3
HY-P990042 Gotistobart Inhibitor ≥99.0% Phase 3
HY-P990690 Volrustomig Inhibitor ≥99.0% Phase 3
HY-P99484 Botensilimab Inhibitor 99.00% Phase 3
HY-P99166 Vudalimab Inhibitor ≥99.0% Phase 2
HY-P99714 Lorigerlimab Inhibitor 97.5% Phase 2
HY-P99514 Zalifrelimab Inhibitor 98.28% Phase 2
HY-P990048 Muzastotug Inhibitor 99.48% Phase 2
HY-P99809 Quavonlimab Inhibitor ≥99.0% Phase 2
HY-P990080 Sovipostobart Inhibitor 96.528% Phase 2
HY-P990739 Evalstotug 95.062% Phase 2
HY-P990775 Vilastobart 99.63% Phase 2
HY-P991566 KD6001 Inhibitor / Phase 2
HY-P991960 JS007 / Phase 2
HY-P990703 Porustobart 99.70% Phase 1
HY-P99844 Davoceticept 99.9% Phase 1
HY-P990041 Firastotug Inhibitor 98.62% Phase 1
HY-P99709 Lodapolimab Inhibitor 99.71% Phase 1
HY-P99760 Nurulimab Inhibitor 95.00% Phase 1
HY-P99354 Bavunalimab 99.408% Phase 1
HY-P991952 ADU-1604 Inhibitor / Phase 1
HY-P991953 BAT4706 / Phase 1
HY-P991961 REGN4659 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-159692 AZD8701 Inhibitor 96.61% Unkown
HY-120120 DZ-2384 Inhibitor / Unkown
HY-122081 CPI-644 Inhibitor / Unkown
HY-RS03299 CTLA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03300 Ctla4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03301 Ctla4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179228 AN02 / Unkown
Inhibitory Antibodies (17)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P99132 Anti-Mouse CTLA-4 Antibody (9D9) Inhibitor 98.91% Unkown
HY-108829A Abatacept (powder) Inhibitor 99.01% Unkown
HY-P990789 Anti-Mouse CTLA-4 Antibody (9H10) Inhibitor 99% Unkown
HY-P99943 Erfonrilimab 99.98% Unkown
HY-P990256 Anti-Mouse CTLA-4/CD152 (LALA-PG) Antibody (9D9) Inhibitor 98.68% Unkown
HY-P990945 Tazlestobart 99.66% Unkown
HY-P990722 Danvilostomig 98.38% Unkown
HY-P991139 Futermestotug Inhibitor 99.84% Unkown
HY-P990848 Anti-CTLA-4/CD152 Antibody (BN13) Inhibitor / Unkown
HY-P991951 ABA04 / Unkown
HY-P991959 JMW-3B3 Inhibitor / Unkown
HY-P992062 Anti-Mouse CD80 Antibody (TKMG48) Agonist / Unkown
HY-P992177 AI-025 Inhibitor / Unkown
HY-P992511 CS2009 Inhibitor / Unkown
HY-P991775 Anti-Rat CTLA-4 Antibody (WKH203) Inhibitor / Unkown
HY-P991827 Anti-Mouse CTLA-4 Antibody (UC10-4F10-11) Inhibitor / Unkown
HY-P991958 GIGA-564 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctla4 NCBI NCBI:1493