2. Immunology/Inflammation
  3. CD3
  4. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 

製品番号: HY-P99146 純度: ≥95.0%
COA Technical Support

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for researches on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer.

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Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 構造式

容量 価格（税別） 在庫状況 数量
1 mg $215 在庫あり
5 mg $580 在庫あり
10 mg $985 在庫あり
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製品説明

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) is an anti-mouse TCR gamma/delta IgG monoclonal antibody. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can enter the blood-brain barrier. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) effectively depletes γδ T cells and reduces macrophage and neutrophil infiltration. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can reduce the immune response of transplants. Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) can be used for researches on inflammation conditions, virus infection and cancer such as arthritis, JHM virus and breast cancer[1][2][3].

Isotype

Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity

Mouse
体外実験

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, 2 days) significantly reduces the number of γδ T cells in spleen and lymph nodes of mice[2].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (5 μg/mL, 48 h) enhances IFN-γ production in γδ T cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) 関連抗体

ELISA Assay[3]

Cell Line: γδ T cells
Concentration: 5 μg/mL, co-incubation with PSK (100 μg/mL)
Incubation Time: 48 h
Result: Significantly increased the level of IFN-γ to 12823 pg/mL.
体内実験

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (250 μg, i.p., on day 0, 3, 6, 9 and 12) exhausts γδ T cells in the central nervous system (CNS) in TCRβ-/- mice infected with JHM virus[1].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., on day 0, 5 and 10) significantly reduces the incidence rate of arthritis in male B10.RIII mice with an IL-23 induced arthritis[2].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (200 μg, i.p., twice weekly, for 4 weeks) can deplete γδ T cells in neu-transgenic mice bearing MMC tumors[3].
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) (500 µg, i.p., single dose, on day -3) significantly inhibits T cell infiltration in female BDF1 mice with a graft-versus-host disease (GVHD) model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 1000 PFU JHM virus injected TCRβ-/- mice[1]
Dosage: 250 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 3, 6, 9 and 12
Result: Significantly reduced the number of gamma delta T cells.
Reduced the degree of demyelination by 73 %.
Significantly improved clinical scores without limb paralysis.
Animal Model: IL-23 induced male B10.RIII mice (12-14 weeks)[2]
Dosage: 200 μg
Administration: Intraperitoneal injection (i.p.), on day 0, 5 and 10
Result: Significantly reduced the incidence rate of arthritis to 46.15 % (80 % in the control group) and reduced the disease severity score.
Reduced the accumulation of neutrophils in the blood, spleen, bone marrow, and joints.
Significantly reduced serum IL-17A levels and increased IL-27 p28 levels.
Reduced synovial hyperplasia in joints.
Animal Model: 1×106 MMC cells injected neu-transgenic mice[3]
Dosage: 200 μg, combined with PSK (100 mg/kg)
Administration: Intraperitoneal injection (i.p.), twice weekly for 4 weeks
Result: Significantly weakened the anti-tumor effect of PSK and increased tumor volume.
Animal Model: 2×108 splenocytes of B6 mice injected female BDF1 mice (8-10 weeks)[4]
Dosage: 500 µg
Administration: Intraperitoneal injection (i.p.), single dose, on day -3
Result: Significantly inhibited the infiltration of donor derived T cells into intestinal epithelium to 32 %.
Significantly reduced the mitotic index (MI) and apoptosis index (AI) of crypt cells.
Significantly reduced intestinal lesions.
Application

in vivo TCR γ/δ neutralization; in vitro γ/δ T cell stimulation; in vitro γ/δ T cell purification;
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
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参考文献
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Anti-Mouse TCR gamma/delta Antibody (UC7-13D5) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)CD3Cluster of differentiation 3TCR gamma/deltaT cellsarthritisJHMMMCtransplantsGVHDInhibitorinhibitorinhibit

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製品名:
Anti-Mouse TCR gamma/delta Antibody (UC7-13D5)
製品番号:
HY-P99146
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