Anti-RSV F Antibody (R4.C6) 

Anti-RSV F Antibody (R4.C6) is a monoclonal antibody against RSV F, with a K_d of 0.34 nM for the post-fusion RSV F trimer. Anti-RSV F Antibody (R4.C6) recognizes a unique neutralizing epitope spanning epitopes II and IV on both pre-fusion and post-fusion RSV F. Anti-RSV F Antibody (R4.C6) can be used in studies related to respiratory syncytial virus infection^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

Anti-RSV F Antibody (R4.C6) (3.3-90 nM) binds RSV F glycoprotein nanoparticles with high affinity, exhibiting a K_d of 0.07 nM^[1].
Anti-RSV F Antibody (R4.C6) (100-800 nM) binds the full-length RSV F antigenic site II peptide with a K_a of 12.5 nM, with binding dependent on both N- and C-terminal regions of the peptide^[1].
Anti-RSV F Antibody (R4.C6) (0.004-10 μg/mL; 2 hour pre-incubation with virus, 4-5 day incubation with cells) neutralizes RSV/A Long in HEp-2 cells with an IC₅₀ of 1078 ng/mL^[1].
Anti-RSV F Antibody (R4.C6) (20 μg/mL; 5 min) competes with antibodies targeting RSV F antigenic sites IIa, IIb, IV, and VII, indicating it recognizes a unique epitope spanning multiple antigenic regions on post-fusion RSV F₇₁₀^[1].
Anti-RSV F Antibody (R4.C6) (3.3-90 nM) binds post-fusion RSV F trimer with a K_d of 0.34 nM, with higher affinity than binding to the isolated site II peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A0A0X8XRK2

RSV-F

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Xie Q, et al. Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein. PLoS One. 2019;14(2):e0210749. Published 2019 Feb 7.