2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Aquaporin 4 Antibody (YA3204)

Aquaporin 4 Antibody (YA3204)

Cat. No.: HY-P83459
User Guide for Antibodies Technical Support

Aquaporin 4 Antibody (YA3204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 4.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

사이즈 가격 재고 수량
20 μL 견적 받기 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
50 μL 견적 받기 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
100 μL 견적 받기 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
250 μL   견적 받기  
Synthetic products have potential research and development risk.
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • 제품 설명

제품 설명

Aquaporin 4 Antibody (YA3204) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aquaporin 4.
Host

Rabbit
Clonality

Recombinant, Monoclonal
분자량
Predicted band size: 35 kDa;
Observed band size: 35 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human AQP4 aa300-323.
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
선적

Shipping with blue ice.
Background
Function：Forms a water-specific channel (PubMed:19383790, PubMed:7559426, PubMed:8601457). Plays an important role in brain water homeostasis (PubMed:37143309). It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability (By similarity)
Subcellular Localization：Cell membrane; Multi-pass membrane protein; Basolateral cell membrane; Multi-pass membrane protein; Endosome membrane; Cell membrane, sarcolemma; Multi-pass membrane protein; Cell projection
Expression：
Tissue_specificity:Detected in skeletal muscle (PubMed:29055082) . Detected in the stomach, along the basal region of the fundic glands (protein level) (PubMed:8601457) . Detected in the brain, lungs, and skeletal muscle, with extremely low levels in the heart and ovaries (PubMed:7559426, PubMed:8601457) .
Isoforms & Post-Translational Modification：P55087 has 2 isomers: P55087-1: 34830 Da (predicted); P55087-2: 32300 Da (predicted).
Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamate increases conductance by 40% (By similarity);Isoform 2: Palmitoylated on its N-terminal region. Isoform 1: Not palmitoylated
Subunit：Homotetramer (PubMed:19383790). The tetramers can form oligomeric arrays in membranes. The size of the oligomers differs between tissues and is smaller in skeletal muscle than in brain. Interaction between AQP4 oligomeric arrays in close-by cells can contribute to cell-cell adhesion (By similarity). Part of a complex containing MLC1, TRPV4, HEPACAM and ATP1B1 (PubMed:22328087)
Database

Entrez Gene: 361 Human ; 11829 Mouse ; 25293 Rat

SwissProt: P55087 Human ; P55088 Mouse ; P47863 Rat

OMIM: 620448 Human

Research Field

Cell Biology
Synonyms
AQP4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4
각종 서류
User Guide for Antibodies (1077 KB)

Aquaporin 4 Antibody (YA3204) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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상품명:
Aquaporin 4 Antibody (YA3204)
Cat. No.:
HY-P83459
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