2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies
  5. CHD4 Antibody (YA946)

CHD4 Antibody (YA946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CHD4.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Descripciòn

  • Referencias

Descripciòn

CHD4 Antibody (YA946) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to CHD4.
Host

Mouse
Clonality

Monoclonal
Peso molecular
Predicted band size: 218 kDa;
Observed band size: 260 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

Purified recombinant human CHD4 protein fragments expressed in E.coli.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Pureza Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG2b  
Appearance

Liquid
Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity)
Subcellular Localization：Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Expression：
Tissue_specificity:Broad expression
Isoforms & Post-Translational Modification：Q14839 has 2 isomers: Q14839-1: 218005 Da (predicted); Q14839-2: 220848 Da (predicted).
Subunit：Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:10204490, PubMed:15454082, PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9804427).
RRID
Database

Entrez Gene: 1108 Human

SwissProt: Q14839 Human

OMIM: 617159 Human

Research Field

Immunology
Synonyms
CHD4; Chromodomain-helicase-DNA-binding protein 4; CHD-4; ATP-dependent helicase CHD4; Mi-2 autoantigen 218 kDa protein; Mi2-beta
Documentación
SDS (252 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)
Referencias

CHD4 Antibody (YA946) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

Nombre del producto:
CHD4 Antibody (YA946)
Cat. No.:
HY-P81265
Cantidad:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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