Cytochrome P450 26A1 Antibody (YA2259)

製品番号: HY-P82514: データシート SDS COA User Guide for Antibodies
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Cytochrome P450 26A1 Antibody (YA2259) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 26A1.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	在庫あり	Estimated Time of Arrival: December 31
50 μL	$222	在庫あり	Estimated Time of Arrival: December 31
100 μL	$360	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

Cytochrome P450 26A1 Antibody (YA2259) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cytochrome P450 26A1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

分子量

Predicted band size: 56 kDa;

Observed band size: 50 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

O43174

Gene ID

1592 [NCBI]

Immunogen

A synthesized peptide derived from human CYP26A1 aa250-450.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Sensitivity	Endogenous	純度	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:22020119, PubMed:9228017, PubMed:9716180). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (PubMed:22020119, PubMed:9228017, PubMed:9716180). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA (By similarity) (PubMed:9228017). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021)

Subcellular Localization：Endoplasmic reticulum membrane; Peripheral membrane protein; Microsome membrane; Peripheral membrane protein

Expression：
Tissue_specificity:Expressed in most human tissues with highest levels in human liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain (PubMed:9826557) . Expressed at high levels in lung, pancreas, skin and uterus (at protein level) (PubMed:22020119) . Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level) (PubMed:22020119)

Induction:By retinoic acid

Isoforms & Post-Translational Modification：O43174 has 2 isomers: O43174-1: 56199 Da (predicted); O43174-2: 48558 Da (predicted).

Database

Entrez Gene: 1592 Human ; 154985 Rat

SwissProt: O43174 Human ;

OMIM: 602239 Human

Research Field

Cardiovascular

Synonyms

CP26; CYP26; cyp26a1; hP450RAI; P450RAI; P450RAI1

ドキュメンテーション

Select Batch:

データシート (235 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)