2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. FKBP12 Antibody (YA434)

FKBP12 Antibody (YA434) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP12.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

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Beschreibung

FKBP12 Antibody (YA434) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FKBP12.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molekulargewicht
Predicted band size: 12 kDa;
Observed band size: 14 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

Synthetic peptide corresponding to Human FKBP12.AA range:76-108.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000
Sensitivity Endogenous Reinheit Protein A affinity purified.
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol. Preservative: 0.05% Sodium Azide.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Verification Image
WB

  • Western blot analysis of extracts from SH-SY5Y(lane 2(20μg) and SH-SY5Y(lane 3(40μg), U937(lane 4(20μg) ) and U937(lane 5(40μg) ) using FKBP12 (HY-P80400) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in TBST for 2 hour at room temperature. The primary antibody (HY-P80400, 1/1000) and Loading control antibody (GAPDH, HY-P80954, 1/3000) was used in 5% BSA in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (HY-P8004/HY-P8001, 1/10,000) was used for 1 hour at room temperature.

Background
Function：Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Subcellular Localization：Cytoplasm, cytosol; Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side
Subunit：Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (PubMed:9233797). Interacts with ACVR1B and SMAD7 (PubMed:16720724).
RRID
Database

Entrez Gene: 2280 Human ; 14225 Mouse ; 25639 Rat

SwissProt: P62942 Human ; P26883 Mouse ; Q62658 Rat

OMIM: 186945 Human

Research Field

Immunology
Dokumentation
SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)
Verweise

FKBP12 Antibody (YA434) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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FKBP12 Antibody (YA434)
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HY-P80400
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