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  5. Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018)

Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018)

Cat. No.: HY-P81296
User Guide for Antibodies Technical Support

Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-delta 1 Catenin (Tyr228).

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-delta 1 Catenin (Tyr228).
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 108 kDa;
Observed band size: 95,100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Rat, Hamster
SwissProt ID
Gene ID
Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Tyr228 of human delta 1 Catenin
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Phosphorylated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:14610055, PubMed:20371349). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics (PubMed:10207085, PubMed:20371349). Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors (PubMed:17344476)
Subcellular Localization：Cell junction, adherens junction; Cytoplasm; Nucleus; Cell membrane; Cell junction; Nucleus; Nucleus; Nucleus; Cytoplasm; Cytoplasm
Expression：
Tissue_specificity:Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs

Induction:Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure
Isoforms & Post-Translational Modification：O60716 has 32 isomers: O60716-1: 108170 Da (predicted); O60716-2: 107349 Da (predicted); O60716-3: 104977 Da (predicted); O60716-4: 105779 Da (predicted); O60716-5: 104156 Da (predicted); O60716-6: 104958 Da (predicted); O60716-7: 102586 Da (predicted); O60716-8: 101765 Da (predicted); O60716-9: 102063 Da (predicted); O60716-10: 101242 Da (predicted); O60716-11: 98870 Da (predicted); O60716-12: 99673 Da (predicted); O60716-13: 98049 Da (predicted); O60716-14: 98852 Da (predicted); O60716-15: 96479 Da (predicted); O60716-16: 95658 Da (predicted); O60716-17: 96689 Da (predicted); O60716-18: 95868 Da (predicted); O60716-19: 93496 Da (predicted); O60716-20: 94299 Da (predicted); O60716-21: 92675 Da (predicted); O60716-22: 93478 Da (predicted); O60716-23: 91105 Da (predicted); O60716-24: 90284 Da (predicted); O60716-25: 72045 Da (predicted); O60716-26: 71225 Da (predicted); O60716-27: 68852 Da (predicted); O60716-28: 69655 Da (predicted); O60716-29: 68031 Da (predicted); O60716-30: 68834 Da (predicted); O60716-31: 66461 Da (predicted); O60716-32: 65641 Da (predicted).
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ
Subunit：Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin/CDH1, alpha-catenin/CTNNA1, beta-catenin/CTNNB1, and gamma-catenin/JUP (PubMed:15240885, PubMed:20371349).
Database

Entrez Gene: 1500 Human ; 12388 Mouse ; 311163 Rat

SwissProt: O60716 Human ; P30999 Mouse ;

OMIM: 617681 Human

Research Field

Cell Biology
Synonyms
CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
Documentation
User Guide for Antibodies (1077 KB)

Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018)
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