CTNND1 - catenin delta 1 Gene
Also Known as CAS; p120; BCDS2; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
Species: Homo sapiens
About CTNND1
This gene has 52 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 74 phenotypes. Ubiquitous expression in esophagus (RPKM 79.1), skin (RPKM 62.3) and 24 other tissues.
Summary
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
CTNND1 Products (22)
| mRNA | Protein | Name |
|---|---|---|
| NM_001085458.2 | NP_001078927.1 | catenin delta-1 isoform 1ABC |
| NM_001085459.2 | NP_001078928.1 | catenin delta-1 isoform 1AB |
| NM_001085460.2 | NP_001078929.1 | catenin delta-1 isoform 1A |
| NM_001085461.2 | NP_001078930.1 | catenin delta-1 isoform 1A |
| NM_001085462.2 | NP_001078931.1 | catenin delta-1 isoform 1A |
| NM_001085463.2 | NP_001078932.1 | catenin delta-1 isoform 3ABC |
| NM_001085464.2 | NP_001078933.1 | catenin delta-1 isoform 3AB |
| NM_001085465.2 | NP_001078934.1 | catenin delta-1 isoform 3B |
| NM_001085466.2 | NP_001078935.1 | catenin delta-1 isoform 3AC |
| NM_001085467.2 | NP_001078936.1 | catenin delta-1 isoform 3A |
| NM_001085468.2 | NP_001078937.1 | catenin delta-1 isoform 3A |
| NM_001085469.2 | NP_001078938.1 | catenin delta-1 isoform 3A |
| NM_001206883.2 | NP_001193812.1 | catenin delta-1 isoform 2ABC |
| NM_001206884.2 | NP_001193813.1 | catenin delta-1 isoform 2AC |
| NM_001206885.2 | NP_001193814.1 | catenin delta-1 isoform 1AC |
| NM_001206886.2 | NP_001193815.1 | catenin delta-1 isoform 2AB |
| NM_001206887.2 | NP_001193816.1 | catenin delta-1 isoform 2B |
| NM_001206888.2 | NP_001193817.1 | catenin delta-1 isoform 2A |
| NM_001206889.2 | NP_001193818.1 | catenin delta-1 isoform 2A |
| NM_001206890.2 | NP_001193819.1 | catenin delta-1 isoform 3A |
| NM_001206891.2 | NP_001193820.1 | catenin delta-1 isoform 2A |
| NM_001331.3 | NP_001322.1 | catenin delta-1 isoform 1B |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cadherin binding |
IDA
IDA: Inferred from direct assay
|
15240885 | GOA |
| enables cadherin binding |
IPI
IPI: Inferred from physical interaction
|
10725230 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10207085 | GOA |
| enables protein sequestering activity |
IDA
IDA: Inferred from direct assay
|
21998202 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
19332538 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in cell-cell adhesion mediated by cadherin |
IMP
IMP: Inferred from mutant phenotype
|
14610055 | GOA |
| involved in negative regulation of canonical Wnt signaling pathway |
IMP
IMP: Inferred from mutant phenotype
|
20123964 | GOA |
| involved in protein stabilization |
IMP
IMP: Inferred from mutant phenotype
|
14610055 | GOA |
| involved in regulation of postsynaptic membrane neurotransmitter receptor levels |
IDA
IDA: Inferred from direct assay
|
18602475 | GOA |
| involved in regulation of postsynaptic membrane neurotransmitter receptor levels |
IEP
IEP: Inferred from expression pattern
|
18602475 | GOA |
| involved in regulation of postsynaptic membrane neurotransmitter receptor levels |
IMP
IMP: Inferred from mutant phenotype
|
18602475 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of catenin complex |
IDA
IDA: Inferred from direct assay
|
28051089 | GOA |
| is active in cell surface |
IDA
IDA: Inferred from direct assay
|
17047063 | GOA |
| located in cell-cell junction |
IDA
IDA: Inferred from direct assay
|
12370829 | GOA |
| is active in cytoplasm |
IDA
IDA: Inferred from direct assay
|
21998202 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
17047063 | GOA |
| located in cytosol |
IMP
IMP: Inferred from mutant phenotype
|
20123964 | GOA |
| located in midbody |
IDA
IDA: Inferred from direct assay
|
15166316 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
20123964 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
17115030 | GOA |
| located in plasma membrane |
IMP
IMP: Inferred from mutant phenotype
|
20123964 | GOA |
CTNND1 Protein Structure
Arm: Armadillo/beta-catenin-like repeat (398 - 436)
Arm: Armadillo/beta-catenin-like repeat (440 - 481)
Arm: Armadillo/beta-catenin-like repeat (703 - 738)
- 0
- 200
- 400
- 600
- 800
- 968 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
catenin delta-1 |
|
CTNND1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CTNND1 | O60716 | CDH2 | Homo sapiens | P19022 | 21357690 | |
|
Intra
|
CTNND1 | O60716 | CDH2 | Homo sapiens | P19022 | 33961781 | |
|
Intra
|
CTNND1 | O60716 | PTPRJ | Homo sapiens | Q12913 | 12370829 | |
|
Intra
|
CTNND1 | O60716 | ZBTB33 | Homo sapiens | Q86T24 | 33961781 | |
|
Intra
|
CTNND1 | O60716 | ZBTB33 | Homo sapiens | Q86T24 | 10207085 | |
|
Intra
|
CTNND1 | O60716 | EGFR | Homo sapiens | P00533 | 31980649 | |
|
Intra
|
CTNND1 | O60716 | EGFR | Homo sapiens | P00533 | 24658140 | |
|
Intra
|
CTNND1 | O60716 | PLPP3 | Homo sapiens | O14495 | 20123964 | |
|
Intra
|
CTNND1 | O60716 | PLPP3 | Homo sapiens | O14495 | 20123964 | |
|
Intra
|
CTNND1 | O60716 | PLPP3 | Homo sapiens | O14495 | 20123964 | |
|
Intra
|
CTNND1 | O60716 | PLPP3 | Homo sapiens | O14495 | 20123964 |
CTNND1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81296 | Phospho-delta 1 Catenin (Tyr228) Antibody (YA1018) | WB, ICC/IF, IP | Rat, Hamster |
| HY-P81296A | Phospho-delta 1 Catenin (Ser268) Antibody (YA1019) | WB | Human, Mouse |
| HY-P81296AA | Phospho-delta 1 Catenin (Ser268) Antibody (YA1019)(PBS only) | WB | Human, Mouse |
| HY-P81296B | Phospho-delta 1 Catenin (Thr916) Antibody (YA1020) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse |
| HY-P81296BA | Phospho-delta 1 Catenin (Thr916) Antibody (YA1020)(PBS only) | WB, IHC-F, IHC-P, ICC/IF | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Blepharocheilodontic Syndrome 2 |
|
|
| Cleft Lip With Or Without Cleft Palate |
|
|
| Blepharocheilodontic Syndrome 1 |
|
|
| Euryblepharon |
|
|
| Pulmonary Sclerosing Hemangioma |
|
|
| Ectropion |
|
|
| Distichiasis |
|
|
| Cleft Lip |
|
|
| Esophagus Carcinoma In Situ |
|
|
| Lobular Neoplasia |
|
|
| Colon Adenocarcinoma |
|
|
| Breast Lobular Carcinoma |
|
|
| Cri-Du-Chat Syndrome |
|
|
| Colorectal Cancer |
|
|
| Diffuse Gastric And Lobular Breast Cancer Syndrome |
|
|
| Diffuse Gastric Cancer |
|
|
| Endometrial Cancer |
|
|
| Ectodermal Dysplasia |
|
|
| Hepatocellular Carcinoma |
|
|
| Melanoma |
|
|
| Tooth Agenesis |
|
|
| Lung Cancer |
|
|
| Prostate Cancer |
|
|
| Pancreatic Cancer |
|
|
| Gastric Cancer |
|
|
| Breast Cancer |
|
|
| Inflammatory Bowel Disease |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | CTNND1 | VGNC | VGNC:71546 |
| Rattus norvegicus | CTNND1 | RGD | RGD:1305643 |
| Mus musculus | CTNND1 | MGD | MGI:105100 |
| Felis catus | CTNND1 | VGNC | VGNC:61258 |
| Bos taurus | CTNND1 | VGNC | VGNC:27805 |
| Canis familiaris | CTNND1 | VGNC | VGNC:103669 |
| Others | CTNND1 | NCBI |