2. Gene
  3. PLPP3 - phospholipid phosphatase 3 Gene

PLPP3 - phospholipid phosphatase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as LPP3; VCIP; Dri42; PAP2B; PPAP2B

Gene ID: 8613 | Gene type: protein coding

About PLPP3

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,494,761-56,579,563 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PLPP3 Products(1)

mRNA Protein Name
NM_003713.5 NP_003704.3 phospholipid phosphatase 3

PLPP3 Protein Structure

PAP2

PAP2: PAP2 superfamily (131 - 275)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 3

PAP2 beta

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10736 PLPP3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLPP3 VGNC VGNC:100040
Rattus norvegicus PLPP3 RGD RGD:620454
Mus musculus PLPP3 MGD MGI:1915166
Canis familiaris PLPP3 VGNC VGNC:44707
Bos taurus PLPP3 VGNC VGNC:33046