PLPP3 - phospholipid phosphatase 3 Gene

Also Known as LPP3; VCIP; Dri42; PAP2B; PPAP2B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8613

About PLPP3

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,494,761-56,579,563 (from NCBI)

This gene has 5 transcripts (splice variants), 279 orthologues and 9 paralogues. Broad expression in thyroid (RPKM 205.6), placenta (RPKM 102.2) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the phosphatidic Acid Phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by Phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]

PLPP3 Products (1)

mRNA Protein Name
NM_003713.5 NP_003704.3 phospholipid phosphatase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ceramide-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
9705349 GOA
enables integrin binding IDA
IDA: Inferred from direct assay
12660161 GOA
enables phosphatidate phosphatase activity IDA
IDA: Inferred from direct assay
9305923 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20123964 GOA
enables sphingosine-1-phosphate phosphatase activity IDA
IDA: Inferred from direct assay
9305923 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion mediated by integrin IDA
IDA: Inferred from direct assay
12660161 GOA
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
9305923 GOA
involved in homotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
20123964 GOA
acts upstream of integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
12660161 GOA
involved in negative regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20123964 GOA
involved in phospholipid dephosphorylation IDA
IDA: Inferred from direct assay
9305923 GOA
involved in phospholipid metabolic process IDA
IDA: Inferred from direct assay
9305923 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20123964 GOA
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
20123964 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
20123964 GOA
involved in protein stabilization IDA
IDA: Inferred from direct assay
20123964 GOA
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
23591818 GOA
involved in sphingosine metabolic process IDA
IDA: Inferred from direct assay
9305923 GOA
involved in wound healing IMP
IMP: Inferred from mutant phenotype
20123964 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
23591818 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
14527693 GOA
located in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
23591818 GOA
located in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: Inferred from direct assay
23591818 GOA
located in membrane IDA
IDA: Inferred from direct assay
9305923 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
17005594 GOA
located in trans-Golgi network IDA
IDA: Inferred from direct assay
23591818 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLPP3 Protein Structure

PAP2

PAP2: PAP2 superfamily (131 - 275)

  • 0
  • 100
  • 200
  • 311 a.a.
Protein Preferred Names Protein Names

phospholipid phosphatase 3

  • PAP2 beta

PLPP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLPP3 O14495 CTNND1 Homo sapiens O60716
Pull Down
20123964
Intra
PLPP3 O14495 CTNND1 Homo sapiens O60716
Confocal
20123964
Intra
PLPP3 O14495 CTNND1 Homo sapiens O60716
Anti Tag CoIP
20123964
Intra
PLPP3 O14495 CTNND1 Homo sapiens O60716
Anti Bait CoIP
20123964
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10736 PLPP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20464 Plpp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26973 Plpp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLPP3 VGNC VGNC:100040
Rattus norvegicus PLPP3 RGD RGD:620454
Mus musculus PLPP3 MGD MGI:1915166
Canis familiaris PLPP3 VGNC VGNC:44707
Bos taurus PLPP3 VGNC VGNC:33046
Others PLPP3 NCBI