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  4. Monoclonal Antibodies Recombinant Antibodies
  5. TrpV5 Antibody (YA2284)

TrpV5 Antibody (YA2284)

Art. -Nr.: HY-P82539
User Guide for Antibodies Technical Support

TrpV5 Antibody (YA2284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

Beschreibung

TrpV5 Antibody (YA2284) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molekulargewicht
Predicted band size: 83 kDa;
Observed band size: 83 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human TRPV5
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IP
IP: Immunoprecipitation
1:20
Sensitivity Endogenous Reinheit Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)
Subcellular Localization：Apical cell membrane; Multi-pass membrane protein
Expression：
Tissue_specificity:Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum
Isoforms & Post-Translational Modification：Q9NQA5 has 2 isomers: Q9NQA5-1: 82562 Da (predicted); Q9NQA5-2: 43167 Da (predicted).
Glycosylated
Subunit：Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (By similarity). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation
Database

Entrez Gene: 56302 Human ; 194352 Mouse ; 116469 Rat

SwissProt: Q9NQA5 Human ; P69744 Mouse ; Q9JIP0 Rat

OMIM: 606679 Human

Research Field

Signal Transduction
Synonyms
CAT2; ECAC1; OTRPC3
Dokumentation
User Guide for Antibodies (1077 KB)

TrpV5 Antibody (YA2284) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TrpV5 Antibody (YA2284)
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