Antifungal agent 40

製品番号: HY-151437: Data Sheet 取扱説明書
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Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation.

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Antifungal agent 40 構造式

CAS 番号 : 3033702-89-2

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50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
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製品説明

IC₅₀ & Target

CYP51^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	5.18 3 Compound: A03	Cytotoxicity against human HL-60 cells by MTT assay Cytotoxicity against human HL-60 cells by MTT assay	[PMID: 36057236]
HL-60	IC₅₀	5.18 3 Compound: A03	Cytotoxicity against human HL-60 cells by MTT assay Cytotoxicity against human HL-60 cells by MTT assay	[PMID: 36057236]
MDA-MB-231	IC₅₀	3.25 3 Compound: A03	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 36057236]
MDA-MB-231	IC₅₀	3.25 3 Compound: A03	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 36057236]
PC-3	IC₅₀	0.98 3 Compound: A03	Cytotoxicity against human PC-3 cells by MTT assay Cytotoxicity against human PC-3 cells by MTT assay	[PMID: 36057236]
PC-3	IC₅₀	0.98 3 Compound: A03	Cytotoxicity against human PC-3 cells by MTT assay Cytotoxicity against human PC-3 cells by MTT assay	[PMID: 36057236]

体外実験

Antifungal agent 40 (compound A03, 0.25-128 μg/mL) inhibits fungal activity with MIC values of 1-64 μg/mL^[1].
Antifungal agent 40 (1-8 μg/mL, 16 h) inhibits lanosterol 14α-demethylase (CYP51) of C.alb (GC-MS analysis)^[1].
Antifungal agent 40 (0.5 μg/mL, 1.5-24 h) displays antibiofilm activity against FCZ-Resistant C.alb^[1].
Antifungal agent 40 (0-10 μM respectively) shows cytotoxicity against HL-60, MDA-MB-231 and PC-3 cells with IC₅₀ values of 5.18, 3.25, 0.98 μM respectively^[1].
Antifungal agent 40 (2-32 μg/mL, 3 h) displays high hemolysis rate in rabbit erythrocyte^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

490.29

分子式

C₂₂H₂₀Cl₂N₄Se

CAS 番号

3033702-89-2

SMILES

ClC1=CC=C(C([Se]C(C2=CC=C(Cl)C=C2)CN3C=CN=C3)CN4C=CN=C4)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Hang Xu, et al. Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51. Eur J Med Chem. 2022 Aug 28;243:114707. [Content Brief]