2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Asandeutertinib

Asandeutertinib  (Synonyms: asandeutertinibum; Osimertinib-d3; AZD-9291-d3)

Art. -Nr.: HY-15772S3 Reinheit: 99.75%
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Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect.

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Asandeutertinib

Asandeutertinib Chemische Struktur

CAS. Nr. : 1638281-46-5

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Other Forms of Asandeutertinib:

Asandeutertinib Related Antibodies

Top Publications Citing Use of Products

Alle EGFR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Beschreibung

Asandeutertinib (Osimertinib-d3; AZD-9291-d3) is a epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, with antineoplastic effect[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Molekulargewicht

502.63

Formel

C28H30D3N7O2
CAS. Nr.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C(C(NC(C=C)=O)=C1)N(C)CCN(C)C)=C1NC2=NC=CC(C(C3=CC=CC=C34)=CN4C([2H])([2H])[2H])=N2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (248.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9895 mL 9.9477 mL 19.8954 mL
5 mM 0.3979 mL 1.9895 mL 3.9791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9895 mL 9.9477 mL 19.8954 mL 49.7384 mL
5 mM 0.3979 mL 1.9895 mL 3.9791 mL 9.9477 mL
10 mM 0.1990 mL 0.9948 mL 1.9895 mL 4.9738 mL
15 mM 0.1326 mL 0.6632 mL 1.3264 mL 3.3159 mL
20 mM 0.0995 mL 0.4974 mL 0.9948 mL 2.4869 mL
25 mM 0.0796 mL 0.3979 mL 0.7958 mL 1.9895 mL
30 mM 0.0663 mL 0.3316 mL 0.6632 mL 1.6579 mL
40 mM 0.0497 mL 0.2487 mL 0.4974 mL 1.2435 mL
50 mM 0.0398 mL 0.1990 mL 0.3979 mL 0.9948 mL
60 mM 0.0332 mL 0.1658 mL 0.3316 mL 0.8290 mL
80 mM 0.0249 mL 0.1243 mL 0.2487 mL 0.6217 mL
100 mM 0.0199 mL 0.0995 mL 0.1990 mL 0.4974 mL
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Asandeutertinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asandeutertinib1638281-46-5asandeutertinibum Osimertinib-d3 AZD-9291-d3EGFREpidermal growth factor receptorErbB-1HER1Inhibitorinhibitorinhibit

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