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  4. Benzene-1,3,5-tricarboxylic acid

Benzene-1,3,5-tricarboxylic acid  (Synonyms: Trimesic acid)

Cat. No.: HY-78985 Pureté: 99.75%
COA
SDS
Instruction de manipulation Technical Support

Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006).

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Benzene-1,3,5-tricarboxylic acid

Benzene-1,3,5-tricarboxylic acid Chemical Structure

CAS No. : 554-95-0

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
25 g En stock
50 g En stock
100 g En stock
500 g En stock
> 100 g   Obtenir un devis  

* Veuillez sélectionner la quantité avant d'ajouter des articles.

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Other Forms of Benzene-1,3,5-tricarboxylic acid:

Benzene-1,3,5-tricarboxylic acid Related Antibodies

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  • Activité biologique

  • Pureté et documentation

  • Références

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Description

Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006)[1][2].

In Vitro

Benzene-1,3,5-tricarboxylic acid forms hydrogen-bonding interactions with chitosan[2].
Benzene-1,3,5-tricarboxylic acid (10-50 mM) can crosslink chitosan to form stable shear-thinning hydrogels[2].
Chitosan hydrogels cross-linked with Benzene-1,3,5-tricarboxylic acid (10-50 mM) enable sustained release of 5-Fluorouracil (HY-90006), and their release profiles depend on the concentrations of trimesic acid and chitosan as well as pH value[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzene-1,3,5-tricarboxylic acid Related Antibodies
Masse moléculaire

210.14

Formule

C9H6O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C(O)=O)=CC(C(O)=O)=C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (475.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7587 mL 23.7937 mL 47.5873 mL
5 mM 0.9517 mL 4.7587 mL 9.5175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation

Purity: 99.75%

SDS (396 KB)

COA (250 KB) HNMR (120 KB) LCMS (95 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7587 mL 23.7937 mL 47.5873 mL 118.9683 mL
5 mM 0.9517 mL 4.7587 mL 9.5175 mL 23.7937 mL
10 mM 0.4759 mL 2.3794 mL 4.7587 mL 11.8968 mL
15 mM 0.3172 mL 1.5862 mL 3.1725 mL 7.9312 mL
20 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9484 mL
25 mM 0.1903 mL 0.9517 mL 1.9035 mL 4.7587 mL
30 mM 0.1586 mL 0.7931 mL 1.5862 mL 3.9656 mL
40 mM 0.1190 mL 0.5948 mL 1.1897 mL 2.9742 mL
50 mM 0.0952 mL 0.4759 mL 0.9517 mL 2.3794 mL
60 mM 0.0793 mL 0.3966 mL 0.7931 mL 1.9828 mL
80 mM 0.0595 mL 0.2974 mL 0.5948 mL 1.4871 mL
100 mM 0.0476 mL 0.2379 mL 0.4759 mL 1.1897 mL
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Benzene-1,3,5-tricarboxylic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzene-1,3,5-tricarboxylic acid554-95-0Trimesic acidMOFsBiochemical Assay ReagentsMetal-Organic Frameworkshydrogel networksbicyclic peptidesrheumatoid arthritismulti-organ failureseptic shockankylosing spondylitiscachexiaprotein-protein interactions5-fluorouracilchitosanInhibitorinhibitorinhibit

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