Benzene-1,3,5-tricarboxylic acid-d3
Based on 1 Customer Validation
Benzene-1,3,5-tricarboxylic acid-d3 (Trimesic acid-d3) is the deuterium labeled Benzene-1,3,5-tricarboxylic acid (HY-78985). Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006).
For research use only. We do not sell to patients.
- Purity : 99.21%
- CAS No.: 62790-27-6
- Formula: C9H3D3O6
- Molecular Weight:213.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 62790-27-6
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Unlabeled CAS 554-95-0
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Appearance Solid
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Molecular Weight 213.16
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Formula C9H3D3O6
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Color White to off-white
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SMILES
OC(C1=C([2H])C(C(O)=O)=C([2H])C(C(O)=O)=C1[2H])=O
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Synonyms
Trimesic acid-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (586.41 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Lian W, et al. Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist. J Am Chem Soc. 2013 Aug 14;135(32):11990-5. [Content Brief]
[3]. Emani S, et al. Chitosan Hydrogels Cross-Linked with Trimesic Acid for the Delivery of 5-Fluorouracil in Cancer Therapy. Pharmaceutics. 2023 Mar 28;15(4):1084. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.6913 mL | 23.4566 mL | 46.9131 mL | 117.2828 mL |
| 5 mM | 0.9383 mL | 4.6913 mL | 9.3826 mL | 23.4566 mL | |
| 10 mM | 0.4691 mL | 2.3457 mL | 4.6913 mL | 11.7283 mL | |
| 15 mM | 0.3128 mL | 1.5638 mL | 3.1275 mL | 7.8189 mL | |
| 20 mM | 0.2346 mL | 1.1728 mL | 2.3457 mL | 5.8641 mL | |
| 25 mM | 0.1877 mL | 0.9383 mL | 1.8765 mL | 4.6913 mL | |
| 30 mM | 0.1564 mL | 0.7819 mL | 1.5638 mL | 3.9094 mL | |
| 40 mM | 0.1173 mL | 0.5864 mL | 1.1728 mL | 2.9321 mL | |
| 50 mM | 0.0938 mL | 0.4691 mL | 0.9383 mL | 2.3457 mL | |
| 60 mM | 0.0782 mL | 0.3909 mL | 0.7819 mL | 1.9547 mL | |
| 80 mM | 0.0586 mL | 0.2932 mL | 0.5864 mL | 1.4660 mL | |
| 100 mM | 0.0469 mL | 0.2346 mL | 0.4691 mL | 1.1728 mL |
Benzene-1,3,5-tricarboxylic acid-d3 Related Classifications
HY-78985S Related Classifications
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