Benzene-1,3,5-tricarboxylic acid (Synonyms: Trimesic acid)

Name: Benzene-1,3,5-tricarboxylic acid
Brand: MedChemExpress
SKU: HY-78985
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-78985 Reinheit: 99.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006).

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Benzene-1,3,5-tricarboxylic acid Chemische Struktur

CAS. Nr. : 554-95-0

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
25 g	Auf Lager	Estimated Time of Arrival: December 31
50 g	Auf Lager	Estimated Time of Arrival: December 31
100 g	Auf Lager	Estimated Time of Arrival: December 31
500 g	Auf Lager	Estimated Time of Arrival: December 31
> 100 g	Angebot einholen

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Other Forms of Benzene-1,3,5-tricarboxylic acid:

Benzene-1,3,5-tricarboxylic acid-d₃ In-stock

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
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Beschreibung

In Vitro

Benzene-1,3,5-tricarboxylic acid forms hydrogen-bonding interactions with chitosan^[2].
Benzene-1,3,5-tricarboxylic acid (10-50 mM) can crosslink chitosan to form stable shear-thinning hydrogels^[2].
Chitosan hydrogels cross-linked with Benzene-1,3,5-tricarboxylic acid (10-50 mM) enable sustained release of 5-Fluorouracil (HY-90006), and their release profiles depend on the concentrations of trimesic acid and chitosan as well as pH value^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

210.14

Formel

C₉H₆O₆

CAS. Nr.

554-95-0

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC(C(O)=O)=CC(C(O)=O)=C1)O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (475.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.7587 mL	23.7937 mL	47.5873 mL
5 mM	0.9517 mL	4.7587 mL	9.5175 mL
10 mM	0.4759 mL	2.3794 mL	4.7587 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.90 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Reinheit & Dokumentation

Purity: 99.75%

Select Batch:

Data Sheet (292 KB) SDS (396 KB)

COA (250 KB) HNMR (120 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Lian W, et al. Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist. J Am Chem Soc. 2013;135(32):11990-11995. [Content Brief]

[2]. Emani S, et al. Chitosan Hydrogels Cross-Linked with Trimesic Acid for the Delivery of 5-Fluorouracil in Cancer Therapy. Pharmaceutics. 2023;15(4):1084. Published 2023 Mar 28. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.7587 mL	23.7937 mL	47.5873 mL	118.9683 mL
	5 mM	0.9517 mL	4.7587 mL	9.5175 mL	23.7937 mL
	10 mM	0.4759 mL	2.3794 mL	4.7587 mL	11.8968 mL
	15 mM	0.3172 mL	1.5862 mL	3.1725 mL	7.9312 mL
	20 mM	0.2379 mL	1.1897 mL	2.3794 mL	5.9484 mL
	25 mM	0.1903 mL	0.9517 mL	1.9035 mL	4.7587 mL
	30 mM	0.1586 mL	0.7931 mL	1.5862 mL	3.9656 mL
	40 mM	0.1190 mL	0.5948 mL	1.1897 mL	2.9742 mL
	50 mM	0.0952 mL	0.4759 mL	0.9517 mL	2.3794 mL
	60 mM	0.0793 mL	0.3966 mL	0.7931 mL	1.9828 mL
	80 mM	0.0595 mL	0.2974 mL	0.5948 mL	1.4871 mL
	100 mM	0.0476 mL	0.2379 mL	0.4759 mL	1.1897 mL

Benzene-1,3,5-tricarboxylic acid Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzene-1,3,5-tricarboxylic acid554-95-0Trimesic acidMOFsBiochemical Assay ReagentsMetal-Organic Frameworkshydrogel networksbicyclic peptidesrheumatoid arthritismulti-organ failureseptic shockankylosing spondylitiscachexiaprotein-protein interactions5-fluorouracilchitosanInhibitorinhibitorinhibit

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Benzene-1,3,5-tricarboxylic acid (Synonyms: Trimesic acid)

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Other Forms of Benzene-1,3,5-tricarboxylic acid:

Benzene-1,3,5-tricarboxylic acid Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

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Benzene-1,3,5-tricarboxylic acid Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

Benzene-1,3,5-tricarboxylic acid Related Classifications

Keywords:

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SAFETY DATA SHEET (SDS)

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