2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide

Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide 

Cat. No.: HY-174304 Purity: 95.59%
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Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugates for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of Triptolide (HY-32735) and a stable cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810). Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide

Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide Chemical Structure

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Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide Related Antibodies

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Description

Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide is a drug-linker conjugates for ADC. Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide consists of Triptolide (HY-32735) and a stable cleavable linker (Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-Cl) (HY-174810). Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide can be used for the synthesis of antibody-drug conjugates (ADCs)[1].

In Vitro

Bis (vinylsulfonyl) piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide (Compound 19) is a drug-linker conjugate for antibody-drug conjugates (ADCs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide Related Antibodies
Molecular Weight

1039.29

Formula

C46H70N6O15S2Si
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@H]1CN(S(=O)(C=C)=O)CCN1S(=O)(C=C)=O)NCC(N=N2)=CN2CCOCCOCCOCCO[Si](O[C@@H]3[C@]4(O[C@H]4[C@@H]5O[C@@]56[C@]7(CCC8=C([C@@]7(C[C@@H]9O[C@]936)[H])COC8=O)C)C(C)C)(C(C)C)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (48.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9622 mL 4.8110 mL 9.6220 mL
5 mM 0.1924 mL 0.9622 mL 1.9244 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9622 mL 4.8110 mL 9.6220 mL 24.0549 mL
5 mM 0.1924 mL 0.9622 mL 1.9244 mL 4.8110 mL
10 mM 0.0962 mL 0.4811 mL 0.9622 mL 2.4055 mL
15 mM 0.0641 mL 0.3207 mL 0.6415 mL 1.6037 mL
20 mM 0.0481 mL 0.2405 mL 0.4811 mL 1.2027 mL
25 mM 0.0385 mL 0.1924 mL 0.3849 mL 0.9622 mL
30 mM 0.0321 mL 0.1604 mL 0.3207 mL 0.8018 mL
40 mM 0.0241 mL 0.1203 mL 0.2405 mL 0.6014 mL
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Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis(vinylsulfonyl)piperazine-triazole-PEG3-O-diisopropylsilyl-triptolideDrug-Linker Conjugates for ADCPanc 08.13atezolizumabCFPAC-1PD-L1SW1990BxPC-3AsPC-1pancreatic cancertriptolidePanc 1005Inhibitorinhibitorinhibit

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