2. Anticuerpos inhibidores
  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. Blosozumab

Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis.

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No. CAS : 1132758-87-2

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Blosozumab Related Antibodies

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Descripciòn

Blosozumab (LY2541546) is an anti-Human sclerostin (SOST) antibody inhibitor. Blosozumab stimulates bone formation and reduces bone resorption. Blosozumab can be used in the research of Osteoporosis[1][2].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

SOST/Sclerostin
In Vivo

Blosozumab (1-100 mg/kg, i.v.) shows effects of hyperostosis in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats [2]
Dosage: 1, 10, and 100 mg/kg
Administration: Intravenous injection (i.v.), once every 3 days (5-week study) or once weekly (6-month study)
Result: Observed the bone anabolic effects.
Showed significant bleeding and morbidity at 100 mg/kg.
Decreases in the numbers of platelets.
Increased number of bone marrow megakaryocytes at 100 mg/kg.
Ensayo clínico
Gene ID

50964  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

144.88 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Blosozumab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized SOST Protein, Human (HEK293, His, HY-P70756) can bind Blosozumab. The EC50 for this effect is 42.23 ng/mL.
Pureza y Documentación

Purity: 99.45%

SDS (251 KB)

COA (232 KB) SDS-PAGE (59 KB) SEC-HPLC (142 KB)

Inhibitory Antibodies User Guide (603 KB)
Referencias
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Blosozumab Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Blosozumab1132758-87-2OthersOsteoporosissclerostinplateletsbone formationbone resorptionInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Blosozumab
Cat. No.:
HY-P99186
Cantidad:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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