BMS-1166-N-piperidine-COOH

製品番号: HY-131187 純度: 97.18%: Data Sheet SDS COA 取扱説明書
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BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC₅₀ of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

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BMS-1166-N-piperidine-COOH 構造式

CAS 番号 : 2447066-00-2

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 844	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 844	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$600	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1050	在庫あり	Estimated Time of Arrival: December 31
25 mg	$2250	在庫あり	Estimated Time of Arrival: December 31
50 mg	$3600	在庫あり	Estimated Time of Arrival: December 31
100 mg	$5800	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 0 publication(s) in Google Scholar

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1^[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC₅₀ of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation^[2].

分子量

639.14

分子式

C₃₇H₃₅ClN₂O₆

CAS 番号

2447066-00-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (156.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5646 mL	7.8230 mL	15.6460 mL
5 mM	0.3129 mL	1.5646 mL	3.1292 mL
10 mM	0.1565 mL	0.7823 mL	1.5646 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 97.18%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (249 KB) LCMS (96 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Binbin Cheng, et al. Discovery of Novel Resorcinol Diphenyl Ether-Based PROTAC-like Molecules as Dual Inhibitors and Degraders of PD-L1. Eur J Med Chem. 2020 Aug 1;199:112377. [Content Brief]

[2]. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5646 mL	7.8230 mL	15.6460 mL	39.1151 mL
	5 mM	0.3129 mL	1.5646 mL	3.1292 mL	7.8230 mL
	10 mM	0.1565 mL	0.7823 mL	1.5646 mL	3.9115 mL
	15 mM	0.1043 mL	0.5215 mL	1.0431 mL	2.6077 mL
	20 mM	0.0782 mL	0.3912 mL	0.7823 mL	1.9558 mL
	25 mM	0.0626 mL	0.3129 mL	0.6258 mL	1.5646 mL
	30 mM	0.0522 mL	0.2608 mL	0.5215 mL	1.3038 mL
	40 mM	0.0391 mL	0.1956 mL	0.3912 mL	0.9779 mL
	50 mM	0.0313 mL	0.1565 mL	0.3129 mL	0.7823 mL
	60 mM	0.0261 mL	0.1304 mL	0.2608 mL	0.6519 mL
	80 mM	0.0196 mL	0.0978 mL	0.1956 mL	0.4889 mL
	100 mM	0.0156 mL	0.0782 mL	0.1565 mL	0.3912 mL