1. PROTAC
    Immunology/Inflammation
  2. PROTAC
    PD-1/PD-L1
  3. PROTAC PD-1/PD-L1 degrader-1

PROTAC PD-1/PD-L1 degrader-1 

Cat. No.: HY-131183
Handling Instructions

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 degrader, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner .

For research use only. We do not sell to patients.

PROTAC PD-1/PD-L1 degrader-1 Chemical Structure

PROTAC PD-1/PD-L1 degrader-1 Chemical Structure

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Description

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 degrader, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner [1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%[1].
PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively[1].

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1-10 μM
Incubation Time: 24 hours
Result: Reduced PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively.
Molecular Weight

1076.59

Formula

C₅₉H₅₈ClN₇O₁₁

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCCC(N4CCN(C(C5N(CC6=CC(Cl)=C(OCC7=CC=CC(C8=CC=C9OCCOC9=C8)=C7C)C=C6OCC%10=CC=CC(C#N)=C%10)CCCC5)=O)CC4)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PROTAC PD-1/PD-L1 degrader-1PROTACPD-1/PD-L1Proteolysis-targeting chimeraPD-1/Programmed death-ligand 1degraderimmunitylysosome-dependentCD3TcellsMDA-MB-231Inhibitorinhibitorinhibit

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Product name:
PROTAC PD-1/PD-L1 degrader-1
Cat. No.:
HY-131183
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