1. PROTAC
  2. Ligands for Target Protein for PROTAC
  3. BMS-1166-N-piperidine-COOH

BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

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BMS-1166-N-piperidine-COOH Chemical Structure

BMS-1166-N-piperidine-COOH Chemical Structure

CAS No. : 2447066-00-2

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Based on 1 publication(s) in Google Scholar

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Description

BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2].

Molecular Weight

639.14

Formula

C37H35ClN2O6

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation
References
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BMS-1166-N-piperidine-COOH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BMS-1166-N-piperidine-COOH
Cat. No.:
HY-131187
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