BMS-1166-N-piperidine-COOH
Based on 1 Customer Validation
BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
For research use only. We do not sell to patients.
- Purity: 97.18%
- CAS No.: 2447066-00-2
- Formula: C37H35ClN2O6
- Molecular Weight:639.14
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Immunology/Inflammation Compound Library
HY-L007
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Anti-Cancer Compound Library
HY-L025
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Small Molecule Immuno-Oncology Compound Library
HY-L031
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Anti-Lung Cancer Compound Library
HY-L075
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Target Protein Ligand Library
HY-L129
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
Chemical Information
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CAS No. 2447066-00-2
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Appearance Solid
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Molecular Weight 639.14
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Formula C37H35ClN2O6
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Color White to off-white
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SMILES
O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (156.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Binbin Cheng, et al. Discovery of Novel Resorcinol Diphenyl Ether-Based PROTAC-like Molecules as Dual Inhibitors and Degraders of PD-L1. Eur J Med Chem. 2020 Aug 1;199:112377. [Content Brief]
[2]. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5646 mL | 7.8230 mL | 15.6460 mL | 39.1151 mL |
| 5 mM | 0.3129 mL | 1.5646 mL | 3.1292 mL | 7.8230 mL | |
| 10 mM | 0.1565 mL | 0.7823 mL | 1.5646 mL | 3.9115 mL | |
| 15 mM | 0.1043 mL | 0.5215 mL | 1.0431 mL | 2.6077 mL | |
| 20 mM | 0.0782 mL | 0.3912 mL | 0.7823 mL | 1.9558 mL | |
| 25 mM | 0.0626 mL | 0.3129 mL | 0.6258 mL | 1.5646 mL | |
| 30 mM | 0.0522 mL | 0.2608 mL | 0.5215 mL | 1.3038 mL | |
| 40 mM | 0.0391 mL | 0.1956 mL | 0.3912 mL | 0.9779 mL | |
| 50 mM | 0.0313 mL | 0.1565 mL | 0.3129 mL | 0.7823 mL | |
| 60 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6519 mL | |
| 80 mM | 0.0196 mL | 0.0978 mL | 0.1956 mL | 0.4889 mL | |
| 100 mM | 0.0156 mL | 0.0782 mL | 0.1565 mL | 0.3912 mL |
BMS-1166-N-piperidine-COOH Related Classifications
HY-131187 Related Classifications
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