1. PROTAC
  2. Ligand for Target Protein for PROTAC
  3. BMS-1166-N-piperidine-COOH

BMS-1166-N-piperidine-COOH 

Cat. No.: HY-131187
Handling Instructions

BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

For research use only. We do not sell to patients.

BMS-1166-N-piperidine-COOH Chemical Structure

BMS-1166-N-piperidine-COOH Chemical Structure

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Description

BMS-1166-N-piperidine-COOH, the BMS-1166-based moiety, binds to E3 ligase ligand via a linker to form PROTAC PD-1/PD-L1 degrader-1 (HY-131183) to degrade PD-1/PD-L1[1]. BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[2].

Molecular Weight

639.14

Formula

C₃₇H₃₅ClN₂O₆

SMILES

O=C(C1N(CCCC1)CC2=CC(Cl)=C(C=C2OCC3=CC=CC(C#N)=C3)OCC4=CC=CC(C5=CC=C6OCCOC6=C5)=C4C)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BMS-1166-N-piperidine-COOHLigand for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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Product name:
BMS-1166-N-piperidine-COOH
Cat. No.:
HY-131187
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