BMS 488043 (Synonyms: BMS 043)

製品番号: HY-14135: Data Sheet 取扱説明書
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BMS 488043 (BMS 043) is an orally active and well-tolerated inhibitor of the attachment of human immunodeficiency virus type 1 (HIV-1) to CD4+ lymphocytes.

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BMS 488043 構造式

CAS 番号 : 452296-83-2

容量	価格（税別）	在庫状況	数量
1 mg	$267	お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
5 mg	$657	お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
10 mg	$979	お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
25 mg	$1584	お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	$2162	お問い合わせ 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 mg		お問い合わせ
200 mg		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

HIV アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

HIV HIV-1 HIV-2

生物活性
純度とドキュメンテーション
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製品説明

BMS 488043 (BMS 043) is an orally active and well-tolerated inhibitor of the attachment of human immunodeficiency virus type 1 (HIV-1) to CD4+ lymphocytes^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Cancer cell lines	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against human cervical cancer cells Cytotoxicity against human cervical cancer cells	[PMID: 19769332]
Cancer cell lines	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against human hepatic cancer cells Cytotoxicity against human hepatic cancer cells	[PMID: 19769332]
Cancer cell lines	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against human larynx cancer cells Cytotoxicity against human larynx cancer cells	[PMID: 19769332]
Cancer cell lines	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against human lung cancer cell Cytotoxicity against human lung cancer cell	[PMID: 19769332]
HEK293	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against HEK cells Cytotoxicity against HEK cells	[PMID: 19769332]
HeLa	CC₅₀	>300 μM Compound: 2, BMS-488043	Cytotoxicity against human HeLa cells expressing CD4 assessed as cell viability after 6 days by XTT assay Cytotoxicity against human HeLa cells expressing CD4 assessed as cell viability after 6 days by XTT assay	[PMID: 23200252]
HeLa	CC₅₀	248 μM Compound: 1, BMS-488043	Cytotoxicity against human HeLa cells Cytotoxicity against human HeLa cells	[PMID: 23360431]
HeLa	EC₅₀	0.75 nM Compound: 2, BMS-488043	Antiviral activity against HIV1 JRFL infected in human HeLa cells expressing CD4 and CCR5 assessed as inhibition of single-cycle viral replication by luciferase reporter gene assay Antiviral activity against HIV1 JRFL infected in human HeLa cells expressing CD4 and CCR5 assessed as inhibition of single-cycle viral replication by luciferase reporter gene assay	[PMID: 23200252]
MT2	CC₅₀	>300 μM Compound: 2; BMS-488043	Cytotoxicity against human MT2 cells assessed as decrease in cell viability after 3 days by XTT assay Cytotoxicity against human MT2 cells assessed as decrease in cell viability after 3 days by XTT assay	[PMID: 29920093]
MT2	CC₅₀	>300 μM Compound: 4, BMS-488043	Cytotoxicity against human MT2 cells after 3 days by XTT assay Cytotoxicity against human MT2 cells after 3 days by XTT assay	[PMID: 19769332]
MT2	EC₅₀	3.44 nM Compound: 1, BMS-488043	Antiviral activity against X4-tropic HIV1 LAI infected in MT2 cells Antiviral activity against X4-tropic HIV1 LAI infected in MT2 cells	[PMID: 23360431]
MT2	EC₅₀	5.58 nM Compound: 1, BMS-488043	Antiviral activity against X4-tropic HIV1 NL4-3 infected in MT2 cells Antiviral activity against X4-tropic HIV1 NL4-3 infected in MT2 cells	[PMID: 23360431]
MT2	EC₅₀	8.32 nM Compound: 1, BMS-488043	Antiviral activity against X4-tropic HIV1 MN infected in MT2 cells Antiviral activity against X4-tropic HIV1 MN infected in MT2 cells	[PMID: 23360431]
PBMC	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against human PBMC Cytotoxicity against human PBMC	[PMID: 19769332]
T-cell	CC₅₀	>=120 μM Compound: 4, BMS-488043	Cytotoxicity against human T cell Cytotoxicity against human T cell	[PMID: 19769332]
U-87MG ATCC	CC₅₀	>40000 nM Compound: 2, BMS-488043,BMS-043	Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs	[PMID: 19534463]
U-87MG ATCC	CC₅₀	>40000 nM Compound: 27, BMS-488043	Cytotoxicity against human U87 cells expressing CD4 and CXCR4 Cytotoxicity against human U87 cells expressing CD4 and CXCR4	[PMID: 18052117]
U-87MG ATCC	CC₅₀	>40 μM Compound: 2, BMS-488043,BMS-043	Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs Cytotoxicity against human U87 cells coexpressing CD4, CxCR4 receptors after 72 hrs	[PMID: 19534463]
U-87MG ATCC	CC₅₀	>40 μM Compound: 27, BMS-488043	Cytotoxicity against human U87 cells expressing CD4 and CXCR4 Cytotoxicity against human U87 cells expressing CD4 and CXCR4	[PMID: 18052117]
U-87MG ATCC	IC₅₀	26 nM Compound: 27, BMS-488043	Antiviral activity against HIV1 pseudovirus in U87 cells expressing CD4 and CCR5 after 72 hrs by M33 pseudotyped assay Antiviral activity against HIV1 pseudovirus in U87 cells expressing CD4 and CCR5 after 72 hrs by M33 pseudotyped assay	[PMID: 18052117]

分子量

422.43

分子式

C₂₂H₂₂N₄O₅

CAS 番号

452296-83-2

SMILES

O=C(C1=CNC2=C1C(OC)=CN=C2OC)C(N3CCN(CC3)C(C4=CC=CC=C4)=O)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. George J Hanna, et al. Antiviral activity, pharmacokinetics, and safety of BMS-488043, a novel oral small-molecule HIV-1 attachment inhibitor, in HIV-1-infected subjects. Antimicrob Agents Chemother. 2011 Feb;55(2):722-8. [Content Brief]

BMS 488043 Related Classifications

Inflammation/Immunology Infection

Molarity Calculator
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS 488043452296-83-2BMS 043BMS488043BMS-488043BMS043BMS-043HIVHuman immunodeficiency viruswell-toleratedHIV-1CD4lymphocyteInhibitorinhibitorinhibit

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BMS 488043 (Synonyms: BMS 043)

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The molarity calculator equation

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BMS 488043 (Synonyms: BMS 043)

BMS 488043 関連抗体

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•関連小分子:

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HIV アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

BMS 488043 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

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