2. Cell Cycle/DNA Damage
  3. SWI/SNF Complex
  4. BRG1-IN-1

BRG1-IN-1 (Compound 11d) is a potent inhibitor of SMARCA4/BRG1. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors.

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BRG1-IN-1

BRG1-IN-1 Chemical Structure

CAS No. : 2616813-99-9

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BRG1-IN-1 Related Antibodies

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SMARCA2 SMARCA4 Protein Polybromo-1

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Description

BRG1-IN-1 (Compound 11d) is a potent inhibitor of SMARCA4/BRG1. BRG1-IN-1 shows better efficacy than PFI-3 in sensitizing GBM cells to the antiproliferative and cell death inducing effects of Temozolomide in vitro. BRG1-IN-1 enhances the inhibitor effect of Temozolomide on the growth of subcutaneous GBM tumors[1].

Masse moléculaire

322.38

Formule

C20H19FN2O
CAS No.
SMILES

O=C(/C=C/N1[C@@H]2C[C@H](C1)N(C3=CC=C(F)C=C3)C2)C4=CC=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

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Pureté et documentation
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BRG1-IN-1 Related Classifications

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Keywords:

BRG1-IN-12616813-99-9SWI/SNF ComplexSWI/SNF Family of Chromatin-Remodelling ComplexesBRG1antiproliferativecell deathtemozolomideGBM tumorsInhibitorinhibitorinhibit

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HY-144720
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