2. Inhibitory Antibodies
  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. Burosumab

Burosumab  (Synonyms: KRN23; N5KG1_C10_LH; UX-023)

Cat. No.: HY-P9939 Purity: 99.20%
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Burosumab (KRN23) is a humanized FGF23-neutralizing antibody. By neutralizing FGF23, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 1610833-03-8

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Burosumab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Burosumab

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Burosumab (KRN23) is a humanized FGF23-neutralizing antibody. By neutralizing FGF23, Burosumab blocks its inhibitory effect on renal phosphate reabsorption, thereby increasing serum phosphate levels and improving abnormal bone mineralization. Burosumab can be used in the research of diseases such as X-linked hypophosphatemia (XLH) and osteomalacia[1][2][3].

Isotype

Human IgG1(D356E/L358M) kappa
Species Reactivity

Human
IC50 & Target

FGF23
In Vivo

Burosumab (4-16 mg/kg; subcutaneous injection; once weekly; 2 months) has a beneficial effect on alveolar bone tissue in a mouse model of X-linked hypophosphatemia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4-week-old male Hyp mice (C57BL/6J background) with X-linked hypophosphatemia caused by PHEX gene mutation[3]
Dosage: 4 and 16 mg/kg
Administration: Subcutaneous injection; once weekly; 2 months
Result: Significantly improved dentin/cementum volume, reduced pulp chamber volume to wild-type levels, particularly with 16 mg/kg.
Enhanced alveolar bone volume fraction and mineral density, restored periodontal ligament attachment and acellular cementum continuity.
Decreased osteoid and cementoid accumulation.
Clinical Trial
Gene ID

8074  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
분자량

144.08 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Burosumab]
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized FGF23-N-His can bind Burosumab. The EC50 for this effect is 241 ng/mL.
순도&문서
References
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Burosumab Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Burosumab1610833-03-8KRN23 N5KG1_C10_LH UX-023KRN 23KRN-23UX023UX 023UX-023OthersX-linked hypophosphatemiaXLHInhibitorinhibitorinhibit

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상품명:
Burosumab
Cat. No.:
HY-P9939
수량:
MCE Japan Authorized Agent:

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