2. Cell Cycle/DNA Damage
  3. ATF6
  4. Ceapin-A7

Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings.

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No. CAS : 2323027-38-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Revisión del cliente

Based on 23 publication(s) in Google Scholar

Other Forms of Ceapin-A7:

Ceapin-A7 Related Antibodies

Top Publications Citing Use of Products

    Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Dec 30;9(1):367.  [Abstract]

    Il1b, Tnfa, or Il6 mRNA expressions in LPS-stimulated BMDMs treated with/without L-malate (24 h) in the presence or absence of CEAPIN-A7 (CEAPIN, 8 μM).

    Ceapin-A7 purchased from MedChemExpress. Usage Cited in: J Transl Med. 2025 Aug 5;23(1):860.  [Abstract]

    ATF6 inhibition abolished the effect of RAD51 down-regulation mediated by IVA. 5 μM of ATF6 inhibitor Ceapin-A7, 0.1 µM of IVA and 5 μM of OLA were used. The cells were treated for 72 h. Western blot was performed. HSP90 was the loading control. the results showed that Ceapin-A7 increased RAD51-EGFP levels.

    Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Nov 29;30(1):237.  [Abstract]

    After treating with Ceapin-A7 (6 µM) for 1 h and stimulating with rhMIF for 3 days, flow cytometry was used to analyze the effect of Ceapin-A7 on Th17 cells. *ρ < 0.05

    Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Mol Med. 2024 Nov 29;30(1):237.  [Abstract]

    The expression of ATF6α, STAT3, and RORC in RA patient cells stimulated with rhMIF in the presence of Ceapin-A7 （6 µM; 1 h）.

    Ceapin-A7 purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2022 Dec 16;27(1):110.  [Abstract]

    Immunoblot of GRP78 and CHOP under insulin and PA combined treatment with or without pre-treatment of ATF6α inhibitor Ceapin-A7 (6 μM), PERK inhibitor ISRIB (0.2 μM) and IRE1 inhibitor 4μ8C (50 μM).

    • Actividad biológica

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    • Revisión del cliente

    Descripciòn

    Ceapin-A7 is a selective blocker of ATF6α signaling in response to ER stress, with an IC50 of 0.59 μM. Ceapin-A7 can be used to explore both the mechanism of activation of ATF6α and its role in pathological settings[1].

    IC50 & Target

    0.59 μM (ATF6α)[1]
    In Vitro

    Ceapin-A7 sensitizes cells to ER stress[1].
    Ceapin (0.6-18.9 μM; 4.5 hours) selectively inhibits ATF6α but not ATF6β[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ceapin-A7 Related Antibodies
    Peso molecular

    470.32

    Fòrmula

    C20H12F6N4O3
    No. CAS
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(NC1=CN(CC2=CC=C(C(F)(F)F)C=C2C(F)(F)F)N=C1)C3=NOC(C4=CC=CO4)=C3
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Powder -20°C 3 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvente y solubilidad
    In Vitro: 

    DMSO : 100 mg/mL (212.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1262 mL 10.6311 mL 21.2621 mL
    5 mM 0.4252 mL 2.1262 mL 4.2524 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (5.32 mM); Clear solution; Need ultrasonic

      This protocol yields a clear solution of 2.5 mg/mL.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 12.5 mg/mL (26.58 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Pureza y Documentación

    Purity: 99.95%

    SDS (394 KB)

    COA (248 KB) HNMR (246 KB) RP-HPLC (226 KB) LCMS (340 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1262 mL 10.6311 mL 21.2621 mL 53.1553 mL
    5 mM 0.4252 mL 2.1262 mL 4.2524 mL 10.6311 mL
    10 mM 0.2126 mL 1.0631 mL 2.1262 mL 5.3155 mL
    15 mM 0.1417 mL 0.7087 mL 1.4175 mL 3.5437 mL
    20 mM 0.1063 mL 0.5316 mL 1.0631 mL 2.6578 mL
    25 mM 0.0850 mL 0.4252 mL 0.8505 mL 2.1262 mL
    30 mM 0.0709 mL 0.3544 mL 0.7087 mL 1.7718 mL
    40 mM 0.0532 mL 0.2658 mL 0.5316 mL 1.3289 mL
    50 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0631 mL
    60 mM 0.0354 mL 0.1772 mL 0.3544 mL 0.8859 mL
    80 mM 0.0266 mL 0.1329 mL 0.2658 mL 0.6644 mL
    100 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5316 mL
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    Ceapin-A7 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ceapin-A72323027-38-7ATF6Activating transcription factor 6ATF6-alphaERtoGolgitraffickingendoplasmicreticulumunfolded protein responseUPRstressInhibitorinhibitorinhibit

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