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Centhaquin (Synonyms: Centhaquine; PMZ-2010)

Cat. No.: HY-106690
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Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of  haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models.

For research use only. We do not sell to patients.

Centhaquin Chemical Structure

Centhaquin Chemical Structure

CAS No. : 57961-90-7

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Description

Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of  haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models[1][2].

In Vivo

Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner[1].
Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci[1].
Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR[2].

Animal Model: Landrace/Large White piglets[2]
Dosage: 0.015mg/kg
Administration: Intravenous administration; Adrenaline 0.02mg/kg plus Centhaquin 0.015mg/kg
Result: Added to adrenaline improved ROSC rates in a swine model of VF cardiac arrest.
Molecular Weight

331.45

Formula

C₂₂H₂₅N₃

CAS No.

57961-90-7

SMILES

CC1=CC=CC(N(CC2)CCN2CCC3=NC4=C(C=CC=C4)C=C3)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CenthaquinCenthaquinePMZ-2010PMZ2010PMZ 2010Othershaemorrhagic shocksystemic vascular resistanceInhibitorinhibitorinhibit

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Centhaquin
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HY-106690
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