2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. CGP 20712 A

CGP 20712 A  (Synonyms: CGP 20712 (mesylate))

製品番号: HY-101355B 純度: 99.93%
COA 取扱説明書 Technical Support

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.

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CGP 20712 A

CGP 20712 A 構造式

CAS 番号 : 105737-62-0

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5 mg $350 在庫あり
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50 mg   お問い合わせ  

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Other Forms of CGP 20712 A:

CGP 20712 A 関連抗体

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α adrenergic receptor β adrenergic receptor

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製品説明

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

IC50 & Target

β adrenergic receptor

 

体外実験

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CGP 20712 A 関連抗体
体内実験

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

590.57

分子式

C24H29F3N4O8S
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.CS(=O)(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (169.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6933 mL 8.4664 mL 16.9328 mL
5 mM 0.3387 mL 1.6933 mL 3.3866 mL
10 mM 0.1693 mL 0.8466 mL 1.6933 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.93%

COA (246 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6933 mL 8.4664 mL 16.9328 mL 42.3320 mL
5 mM 0.3387 mL 1.6933 mL 3.3866 mL 8.4664 mL
10 mM 0.1693 mL 0.8466 mL 1.6933 mL 4.2332 mL
15 mM 0.1129 mL 0.5644 mL 1.1289 mL 2.8221 mL
20 mM 0.0847 mL 0.4233 mL 0.8466 mL 2.1166 mL
25 mM 0.0677 mL 0.3387 mL 0.6773 mL 1.6933 mL
30 mM 0.0564 mL 0.2822 mL 0.5644 mL 1.4111 mL
40 mM 0.0423 mL 0.2117 mL 0.4233 mL 1.0583 mL
50 mM 0.0339 mL 0.1693 mL 0.3387 mL 0.8466 mL
60 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7055 mL
80 mM 0.0212 mL 0.1058 mL 0.2117 mL 0.5291 mL
100 mM 0.0169 mL 0.0847 mL 0.1693 mL 0.4233 mL
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CGP 20712 A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 20712 A105737-62-0CGP 20712CGP20712CGP-20712Adrenergic ReceptorBeta ReceptorselectiveadrenoceptorusefultoolInhibitorinhibitorinhibit

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製品名:
CGP 20712 A
製品番号:
HY-101355B
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