2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. CGP 20712 dihydrochloride

CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors.

For research use only. We do not sell to patients.

CGP 20712 dihydrochloride Chemical Structure

CGP 20712 dihydrochloride Chemical Structure

CAS No. : 1216905-73-5

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Based on 1 publication(s) in Google Scholar

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CGP 20712 dihydrochloride Related Antibodies

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Description

CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

Molecular Weight

567.39

Formula

C23H27Cl2F3N4O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 28 mg/mL (49.35 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7625 mL 8.8123 mL 17.6246 mL
5 mM 0.3525 mL 1.7625 mL 3.5249 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7625 mL 8.8123 mL 17.6246 mL 44.0614 mL
5 mM 0.3525 mL 1.7625 mL 3.5249 mL 8.8123 mL
10 mM 0.1762 mL 0.8812 mL 1.7625 mL 4.4061 mL
15 mM 0.1175 mL 0.5875 mL 1.1750 mL 2.9374 mL
20 mM 0.0881 mL 0.4406 mL 0.8812 mL 2.2031 mL
25 mM 0.0705 mL 0.3525 mL 0.7050 mL 1.7625 mL
30 mM 0.0587 mL 0.2937 mL 0.5875 mL 1.4687 mL
40 mM 0.0441 mL 0.2203 mL 0.4406 mL 1.1015 mL
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CGP 20712 dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 207121216905-73-5CGP20712CGP-20712Adrenergic ReceptorBeta ReceptorLipolytic responseInhibitorinhibitorinhibit

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