1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. CGP 20712 A

CGP 20712 A (Synonyms: CGP 20712 mesylate)

Cat. No.: HY-101355B Purity: >98.0%
Handling Instructions

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.

For research use only. We do not sell to patients.

CGP 20712 A Chemical Structure

CGP 20712 A Chemical Structure

CAS No. : 105737-62-0

Size Price Stock
10 mM * 1  mL in DMSO USD 585 Ask For Quote & Lead Time
5 mg USD 450 Ask For Quote & Lead Time
10 mg USD 765 Ask For Quote & Lead Time

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Description

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors[1].

IC50 & Target

IC50: 0.7 nM (β1-adrenoceptor)[1]

In Vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2].

In Vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection[3].

Molecular Weight

590.57

Formula

C₂₄H₂₉F₃N₄O₈S

CAS No.

105737-62-0

SMILES

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (169.33 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6933 mL 8.4664 mL 16.9328 mL
5 mM 0.3387 mL 1.6933 mL 3.3866 mL
10 mM 0.1693 mL 0.8466 mL 1.6933 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

CGP 20712 ACGP 20712CGP20712CGP-20712Adrenergic ReceptorBeta ReceptorselectiveadrenoceptorusefultoolInhibitorinhibitorinhibit

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CGP 20712 A
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