CGP 20712 A (Synonyms: CGP 20712 mesylate)

Cat. No.: HY-101355B Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.

For research use only. We do not sell to patients.

CGP 20712 A Chemical Structure

CAS No. : 105737-62-0

Size	Price	Stock
5 mg	USD 450	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of CGP 20712 A:

CGP 20712 dihydrochloride Get quote

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Biological Activity
Purity & Documentation
References
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Description

CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC₅₀ of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors^[1].

IC₅₀ & Target

β adrenergic receptor

In Vitro

In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

590.57

Formula

C₂₄H₂₉F₃N₄O₈S

CAS No.

105737-62-0

Appearance

Solid

Color

White to yellow

SMILES

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.CS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (169.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6933 mL	8.4664 mL	16.9328 mL
5 mM	0.3387 mL	1.6933 mL	3.3866 mL
10 mM	0.1693 mL	0.8466 mL	1.6933 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. [Content Brief]

[2]. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. [Content Brief]

[3]. Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6933 mL	8.4664 mL	16.9328 mL	42.3320 mL
	5 mM	0.3387 mL	1.6933 mL	3.3866 mL	8.4664 mL
	10 mM	0.1693 mL	0.8466 mL	1.6933 mL	4.2332 mL
	15 mM	0.1129 mL	0.5644 mL	1.1289 mL	2.8221 mL
	20 mM	0.0847 mL	0.4233 mL	0.8466 mL	2.1166 mL
	25 mM	0.0677 mL	0.3387 mL	0.6773 mL	1.6933 mL
	30 mM	0.0564 mL	0.2822 mL	0.5644 mL	1.4111 mL
	40 mM	0.0423 mL	0.2117 mL	0.4233 mL	1.0583 mL
	50 mM	0.0339 mL	0.1693 mL	0.3387 mL	0.8466 mL
	60 mM	0.0282 mL	0.1411 mL	0.2822 mL	0.7055 mL
	80 mM	0.0212 mL	0.1058 mL	0.2117 mL	0.5291 mL
	100 mM	0.0169 mL	0.0847 mL	0.1693 mL	0.4233 mL

CGP 20712 A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 20712 A105737-62-0CGP 20712CGP20712CGP-20712Adrenergic ReceptorBeta ReceptorselectiveadrenoceptorusefultoolInhibitorinhibitorinhibit

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