Ciraparantag acetate  (Synonyms: PER977 acetate)

Ciraparantag (PER977) acetate is a thrombin and factor Xa inhibitor. Ciraparantag acetate is a broad-spectrum reversal agent for anticoagulants, including low molecular weight heparins, unfractionated heparins, and some direct oral anticoagulants, but not VKAs^[1][2][3][4].

Ciraparantag acetate is a small synthetic and cationic molecule that binds direct Xa inhibitors, direct thrombin inhibitors, and unfractionated and low molecular weight heparin (LMWH) through non-covalent hydrogen bonds and charge–charge interactions^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In rat-tail transection bleeding assays, Ciraparantag (PER977) acetate demonstrates reversal of anticoagulants with thromboelastography studies and reduced bleeding^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₂₂H₄₈N₁₂O₂.xC₂H₄O₂

1644388-83-9

Solid

White to off-white

O=C(NCCCN1CCN(CCCNC([C@@H](N)CCCNC(N)=N)=O)CC1)[C@@H](N)CCCNC(N)=N.CC(O)=O.[x]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Das A, et al. Novel antidotes for target specific oral anticoagulants. Exp Hematol Oncol. 2015 Sep 15;4:25. [Content Brief]  [Content Brief]

  [2]. Gomez-Outes A, et al. Specific antidotes in development for reversal of novel anticoagulants: a review. Recent Pat Cardiovasc Drug Discov. 2014;9(1):2-10. [Content Brief]  [Content Brief]

  [3]. Hu TY, et al. Reversing anticoagulant effects of novel oral anticoagulants: role of ciraparantag, andexanet alfa, and idarucizumab. Vasc Health Risk Manag. 2016 Feb 17;12:35-44. [Content Brief]  [Content Brief]

  [4]. Honickel M, et al. The Reversal of Direct Oral Anticoagulants in Animal Models. Shock. 2017 Aug;48(2):144-158. [Content Brief]  [Content Brief]