2. Anti-infection
  3. Bacterial
  4. Cyclo(L-Pro-L-Val)

Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

カスタムペプチド

Cyclo(L-Pro-L-Val)

Cyclo(L-Pro-L-Val) 構造式

CAS 番号 : 2854-40-2

容量 価格（税別） 在庫状況 数量
5 mg $32 在庫あり
10 mg $50 在庫あり
25 mg $80 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of Cyclo(L-Pro-L-Val):

Cyclo(L-Pro-L-Val) 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases[1][2].

Cellular Effect
Cell Line Type Value Description References
HCT-116 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
>100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
[PMID: 36518704]
HEK293 EC50
>100 3
Compound: DKPPVal
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
HCT-116 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human BCRP incubated for 48 hrs by MTT assay
[PMID: 36518704]
Neutrophil IC50
2.79 6
Compound: 28
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
[PMID: 21848266]
HCT-116 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells overexpressing human MDR1 incubated for 48 hrs by MTT assay
[PMID: 36518704]
HEK293 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
HEK293 EC50
> 100 3
Compound: DKPPVal
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells incubated for 48 hrs by MTT assay
[PMID: 36518704]
Neutrophil IC50
6.59 6
Compound: 28
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
[PMID: 21848266]
Neutrophil IC50
2.79 6
Compound: 28
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced elastase release
[PMID: 21848266]
Neutrophil IC50
6.59 6
Compound: 28
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
Anti-inflammatory activity in human neutrophils assessed as inhibition of FMLP/CB-induced superoxide anion generation
[PMID: 21848266]
体外実験

Cyclo(L-Pro-L-Val) (MIC=19.6 mg/mL) shows toxic activity comparable to that of 25 mg/mL Chloramphenicol (HY-B0239) in the antibacterial experiment against Rhodococcus fascians LMG 3605 and could reduce the viability of Rhodococcus fascians LMG 3605 cells[1]Cyclo(L-Pro-L-Val) (25-100 μM; treated for 1 hour and then co-incubated with LPS for 24 hours) significantly inhibits the production of NO in RAW 264.7 macrophages stimulated by LPS in the anti-inflammatory experiment of RAW 264.7 macrophages, and the inhibitory effect is equivalent to that of L-NMMA (HY-18732)[2]Cyclo(L-Pro-L-Val) (50-100 μM；24 h) inhibits the phosphorylation of IKKα, IKKβ, and NF-κB, as well as the activation of iNOS and COX-2 in RAW 264.7 macrophages induced by LPS in a concentration-dependent manner[2]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclo(L-Pro-L-Val) 関連抗体

Western Blot Analysis[2]

Cell Line: RAW 264.7 macrophages
Concentration: 50 μM, 100 μM
Incubation Time: Treated for 1 hour and then co-incubated with 1 μg/mL LPS for 24 h
Result: Significantly inhibited expression of IKKα/β, I-κBα, and NF-κB in a concentration dependent manner.
分子量

196.25

分子式

C10H16N2O2
CAS 番号
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Pro-Val)
Sequence Shortening

Cyclo(PV)
Structure Classification
Initial Source

Streptomyces strain ML 1532
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (509.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0955 mL 25.4777 mL 50.9554 mL
5 mM 1.0191 mL 5.0955 mL 10.1911 mL
10 mM 0.5096 mL 2.5478 mL 5.0955 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.0955 mL 25.4777 mL 50.9554 mL 127.3885 mL
5 mM 1.0191 mL 5.0955 mL 10.1911 mL 25.4777 mL
10 mM 0.5096 mL 2.5478 mL 5.0955 mL 12.7389 mL
15 mM 0.3397 mL 1.6985 mL 3.3970 mL 8.4926 mL
20 mM 0.2548 mL 1.2739 mL 2.5478 mL 6.3694 mL
25 mM 0.2038 mL 1.0191 mL 2.0382 mL 5.0955 mL
30 mM 0.1699 mL 0.8493 mL 1.6985 mL 4.2463 mL
40 mM 0.1274 mL 0.6369 mL 1.2739 mL 3.1847 mL
50 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.5478 mL
60 mM 0.0849 mL 0.4246 mL 0.8493 mL 2.1231 mL
80 mM 0.0637 mL 0.3185 mL 0.6369 mL 1.5924 mL
100 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2739 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Cyclo(L-Pro-L-Val) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(L-Pro-L-Val)2854-40-2BacterialInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Cyclo(L-Pro-L-Val)
製品番号:
HY-P1938
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.