2. GPCR/G Protein
  3. GCGR
  4. Dapiglutide

Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects.

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Dapiglutide

Dapiglutide Estructura química

No. CAS : 2296814-85-0

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Based on 1 publication(s) in Google Scholar

Dapiglutide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dapiglutide

  • Actividad biológica

  • Pureza y Documentación

  • Referencias

  • Revisión del cliente

Descripciòn

Dapiglutide (ZP7570) is a long-acting glucagon-like peptide-1 receptor 1R (GLP-1R)/Glucagon-like peptide-2 receptor (GLP-2R) dual agonist. Dapiglutide alleviates intestinal dysfunction in a mouse short bowel model and has anti-obesity effects[1][2][3].

In Vitro

Dapiglutide has an EC50 of 190 pM for GLP-1R and an EC50 of 210 pM for GLP-2R in HEK293 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dapiglutide Related Antibodies
In Vivo

Dapiglutide (6-250 nmol/kg, subcutaneous injection, once daily for three days) effectively alleviates intestinal dysfunction in mice[2].
Dapiglutide (100 nmol/kg, once daily for four weeks) can reduce body weight in obese mice[3].
Pharmacokinetic Analysis in MC38 Syngeneic Model[2]

Route Dose (nmol/kg) Animal T1/2 (h) Tmax (h) F (%)
s.c. 10 Mice 3.6 4.5 71
s.c. 10 Rats 7.7 9.0 58

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A murine SB model of intestinal insufficiency with 40% ileocecal resection[2]
Dosage: 6 and 250 nmol/kg; daily; 3 days
Administration: Subcutaneous injection (s.c.)
Result: Improved oral glucose tolerance, shortened intestinal transit time, promoted intestinal growth, significantly increased villus height and intestinal length, and reduced fecal water loss.
Animal Model: DIO rats[3]
Dosage: 100 nmol/kg; daily; 4 weeks
Administration:
Result: Reduced weight and was more effective when combined with ZP8396.
Ensayo clínico
Peso molecular

4166.79

Fòrmula

C192H302N46O57
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

His-{Aib}-Glu-Gly-Ser-Phe-Thr-Ser-Glu-Leu-Ala-Thr-Ile-Leu-Asp-Lys(γGlu-octadecanedioic acid)-Gln-Ala-Ala-Arg-Asp-Phe-Ile-Ala-Trp-Leu-Ile-Gln-His-Lys-Ile-Thr-Asp
Sequence Shortening

H-{Aib}-EGSFTSELATILD-Lys(γGlu-octadecanedioic acid)-QAARDFIAWLIQHKITD
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (12.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2400 mL 1.2000 mL 2.3999 mL
5 mM 0.0480 mL 0.2400 mL 0.4800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (0.60 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2400 mL 1.2000 mL 2.3999 mL 5.9998 mL
5 mM 0.0480 mL 0.2400 mL 0.4800 mL 1.2000 mL
10 mM 0.0240 mL 0.1200 mL 0.2400 mL 0.6000 mL
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Dapiglutide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dapiglutide2296814-85-0ZP7570ZP 7570ZP-7570GCGRGlucagon ReceptorGLP-1RGLP-2Rlong-actingshortbowelsyndromeInhibitorinhibitorinhibit

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Nombre del producto:
Dapiglutide
Cat. No.:
HY-P3291
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