DDO-2213

Cat. No.: HY-153331 Purity: 98.84%: Data Sheet
COA

SDS
Handling Instructions
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DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC₅₀ of 29 nM and a K_d value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research.

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DDO-2213 화학구조

CAS No. : 2378768-36-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

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고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
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제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HUVEC	IC₅₀	> 100 μM Compound: 63; DDO-2213	Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]
K562	IC₅₀	> 100 μM Compound: 63; DDO-2213	Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]
MOLM-13	GI₅₀	13.09 μM Compound: DDO-2213	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay	[PMID: 34283608]
MOLM-13	IC₅₀	13.1 μM Compound: 63; DDO-2213	Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]
MV4-11	GI₅₀	12.57 μM Compound: DDO-2213	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay	[PMID: 34283608]
MV4-11	IC₅₀	12.6 μM Compound: 63; DDO-2213	Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay	[PMID: 34105966]

분자량

483.97

화학식

C₂₄H₂₇ClFN₇O

CAS No.

2378768-36-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC(NC3=NC=NC(Cl)=C3N)=C(N4CCN(C)CC4)C=C2F)C=C1)N(C)C

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 100 mg/mL (206.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0662 mL	10.3312 mL	20.6624 mL
5 mM	0.4132 mL	2.0662 mL	4.1325 mL
10 mM	0.2066 mL	1.0331 mL	2.0662 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.84%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (251 KB) HNMR (295 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Chen W, et al. Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia. J Med Chem. 2021 Jun 24;64(12):8221-8245. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0662 mL	10.3312 mL	20.6624 mL	51.6561 mL
	5 mM	0.4132 mL	2.0662 mL	4.1325 mL	10.3312 mL
	10 mM	0.2066 mL	1.0331 mL	2.0662 mL	5.1656 mL
	15 mM	0.1377 mL	0.6887 mL	1.3775 mL	3.4437 mL
	20 mM	0.1033 mL	0.5166 mL	1.0331 mL	2.5828 mL
	25 mM	0.0826 mL	0.4132 mL	0.8265 mL	2.0662 mL
	30 mM	0.0689 mL	0.3444 mL	0.6887 mL	1.7219 mL
	40 mM	0.0517 mL	0.2583 mL	0.5166 mL	1.2914 mL
	50 mM	0.0413 mL	0.2066 mL	0.4132 mL	1.0331 mL
	60 mM	0.0344 mL	0.1722 mL	0.3444 mL	0.8609 mL
	80 mM	0.0258 mL	0.1291 mL	0.2583 mL	0.6457 mL
	100 mM	0.0207 mL	0.1033 mL	0.2066 mL	0.5166 mL

DDO-2213 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-22132378768-36-4DDO2213DDO 2213WDR5WD repeat protein-5WD40 repeat domain protein 5MLL Fusion LeukemiaWD repeat-containing protein 5MV4-11 tumorInhibitorinhibitorinhibit

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DDO-2213

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DDO-2213 Related Antibodies

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Biological Activity

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고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

DDO-2213 Related Classifications

Keywords:

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Request for HNMR Report

SAFETY DATA SHEET (SDS)

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