2378768-36-4
Chemical Structure
DDO-2213
- CAS No.: 2378768-36-4
- Formula:C24H27ClFN7O
- Molecular Weight:483.97
IUPAC Name: 5'-((5-amino-6-chloropyrimidin-4-yl)amino)-2'-fluoro-N,N-dimethyl-4'-(4-methylpiperazin-1-yl)-[1,1'-biphenyl]-4-carboxamide
InChIKey: LXONEMNSYOAQJT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC(NC3=NC=NC(Cl)=C3N)=C(N4CCN(C)CC4)C=C2F)C=C1)N(C)C
Biological Activity: DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research[1].
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DDO-2213 | 98.84% | DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research. | ||||||||||||||||||||
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Keywords
