Dextran sulfate sodium salt (MW 6500-10000)  (Synonyms: DSS (MW 6500-10000); DXS (MW 6500-10000))

Dextran sulfate sodium salt (DSS) (MW 6500-10000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. Dextran sulfate sodium salt with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (MW 6500-10000) has antiviral activity against HIV-1 and HIV-2. Dextran sulfate sodium salt (MW 6500-10000) blocks the binding of virions to CD4^⁺ T lymphocytes and inhibits syncytia formation. Dextran sulfate sodium salt (MW 6500-10000) also prevents experimental urolithiasis due to its cytoprotective actions. Moreover, because of its biocompatible and highly charged properties, Dextran sulfate sodium salt (MW 6500-10000) is a suitable choice for pharmaceutical systems^{[1][2][3][4][5][6]}.

Antiviral activity:
Dextran sulfate sodium salt (MW 8000) (6.75 μM, 48 h) inhibits syncytia formation between CD4⁺ ATH8 cells and HIV-1 infected H9 cells^[1].

Cytoprotective activity:
Dextran sulfate sodium salt (MW 6500-10000) (100, 500 μM, 24 h) protects mouse and human β-cells against death induced by the combination of IL-1β, TNF-α, and IFN-γ^[3].
Dextran sulfate sodium salt (MW 6500-10000) (100, 500 μM, 24 h) decreases IFN-γ, TNF-α, and IL-1β signaling pathways in human islets^[3].

Used as coating material:
Dextran sulfate sodium salt (MW 6500-10000) can be used to coat quantum dots to target scavenger receptors on macrophages^[4].
Dextran sulfate sodium salt (MW 6500-10000) can be used to coat PEI-GLU layer (an enzyme multilayer combi-biocatalyst) to generate a more hydrophilic surface^[5].
Dextran sulfate sodium salt (MW 6500-10000) can be used for formulation of Melittin/DS nanocomplex (based on strong electrostatic interactions between positively charged peptides and polyelectrolytes), which overcomes the high acute toxicity and short in vivo half-life of Melittin^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW 8000) (65 mg/kg, dissolved in 0.2 mL saline, i.p., daily) prevents experimental urolithiasis in rats. Possibly, DSS forms soluble complex with calcium ions dissolved in the urine and therefore prevented calcium salt crystallization^[2].
Dextran sulfate sodium salt (MW 6500-10000) (10 mg/kg, i.p., for 4 weeks) prevents T1D development in prediabetic NOD mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6500-10000

9011-18-1

[Dextran sulfate sodium salt]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. 1. Mitsuya H, et al. Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells. Science. 1988 Apr 29;240(4852):646-9.  [Content Brief]

  [2]. 2. Tostes V, et al. Low-molecular-weight dextran sulfate prevents experimental urolithiasis in rats. Clin Chim Acta. 2004 Mar;341(1-2):147-55.  [Content Brief]

  [3]. 3. Lu G, et al. Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes. Diabetes. 2020 Aug;69(8):1692-1707.  [Content Brief]

  [4]. 4. Tu C, et al. Paramagnetic, silicon quantum dots for magnetic resonance and two-photon imaging of macrophages. J Am Chem Soc. 2010 Feb 17;132(6):2016-23.  [Content Brief]

  [5]. 5. Diego Carballares, et al. Preparation of a Six-Enzyme Multilayer Combi-Biocatalyst: Reuse of the Most Stable Enzymes after Inactivation of the Least Stable One. ACS Sustainable Chemistry & Engineering. 10 (1).

  [6]. 6. Gui Z, et al. Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes. Int J Pharm. 2020 Mar 15;577:119071.  [Content Brief]