diABZI STING agonist-1 (tautomerism)

Name: diABZI STING agonist-1 (tautomerism)
Brand: MedChemExpress
SKU: HY-112921
Rating: 5.0 (2 reviews)

Cat. No.: HY-112921 Purity: 99.91%: Data Sheet
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diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921A). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively.

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CAS No. : 2138498-18-5

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of diABZI STING agonist-1 (tautomerism):

diABZI STING agonist-1 In-stock
diABZI STING agonist-1 trihydrochloride In-stock

2 Publications Citing Use of MCE diABZI STING agonist-1 (tautomerism)

: diABZI STING agonist-1 (tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]; Western blot analysis of EVPs isolated from HeLa, HCT116, and B16F10 cells treated with or without 10 µM STING agonist-1 (diABZI), 1 µM cGAMP, or 50 µg/mL DMXAA for 48 h.

: diABZI STING agonist-1 (tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]; Immunofluorescence analysis of STING (green) and Flag-RAB22AQ64L (red) in stable Flag-RAB22AQ64L NCI-H1975 cells treated with or without 1 µM STING agonist-1 (diABZI) for 1 h.

: diABZI STING agonist-1 (tautomerism) purchased from MedChemExpress. Usage Cited in: Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]; Western blot analysis of the WCL of the indicated stable 4T1 cells at the indicated time points after treatment with 10 µM STING agonist-1 (diABZI).

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

EC50: 130 nM (human STNG in PBMCs) ^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
H69AR	EC₅₀	0.035 μM Compound: 5; GSK	Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay	[PMID: 35108011]
H69AR	EC₅₀	0.055 μM Compound: 5; GSK	Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay	[PMID: 35108011]

In Vitro

diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC₅₀s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, diABZI STING agonist-1 (compound 3) demonstrates high selectivity against more than 350 kinases tested^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

diABZI STING agonist-1 (subcutaneous injection; 2.5 mg/kg) tautomerism induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo^[1].
diABZI STING agonist-1 (intravenous injection; 3 mg/kg) tautomerism exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC₅₀) for mouse STING (200 ng/mL)^[1].
diABZI STING agonist-1 (intravenous injection; 1.5 mg/kg; 43 days) tautomerism results in significant tumour growth inhibition and significantly improves survival with 8 out of 10 mice remaining tumor free at the end of the study on day 43^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

849.94

화학식

C₄₂H₅₁N₁₃O₇

CAS No.

2138498-18-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C(N)C1=CC(N/C(N2C/C=C/CN3/C(NC4=C3C(OCCCN5CCOCC5)=CC(C(N)=O)=C4)=N/C(C6=CC(C)=NN6CC)=O)=N\C(C7=CC(C)=NN7CC)=O)=C2C(OC)=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서

Purity: 99.91%

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Data Sheet (280 KB) SDS (252 KB)

COA (263 KB) HNMR (330 KB) RP-HPLC (264 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7. [Content Brief]